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2017 ; 10
(3
): 795-801
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gab.com Text
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Near Complete Response in a Patient with Classical Hodgkin Lymphoma Treated with
Brentuximab Vedotin Concurrent with Radiation Therapy
#MMPMID29158727
Montana W
; Buck DA
; Smith T
Case Rep Oncol
2017[Sep]; 10
(3
): 795-801
PMID29158727
show ga
Brentuximab vedotin, an antibody drug conjugate that delivers monomethyl
auristatin E into CD-30 expressing cells is FDA approved for the treatment of
patients with Hodgkin lymphoma after the failure of autologous stem cell
transplantation or at least 2 prior multi-agent chemotherapy regiments. This
approval was based on a study that showed an overall response rate of 75% and
complete remission in 34%. We present a case of a 24-year-old male with classical
nodular sclerosing Hodgkin lymphoma who achieved near complete remission
following 5 cycles of brentuximab concurrent with ISRT (involved site radiation
therapy) following progression of first-line ABVD (Adriamycin, bleomycin,
vinblastine, dacarbazine) and subsequent second-line ICE (ifosfamide,
carboplatin, etoposide) chemotherapy. This case not only reiterates the efficacy
of brentuximab vedotin in the third-line setting but introduces the role of and
need for further clinical trials of combined radiotherapy with brentuximab in
Hodgkin lymphoma patients following failure of second-line options.