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10.5152/eurjrheum.2017.16117

http://scihub22266oqcxt.onion/10.5152/eurjrheum.2017.16117
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C5685279!5685279!29163999
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suck abstract from ncbi


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pmid29163999      Eur+J+Rheumatol 2017 ; 4 (3): 178-83
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  • Childhood lupus nephritis: 12 years of experience from a developing country?s perspective #MMPMID29163999
  • Samanta M; Nandi M; Mondal R; Hazra A; Sarkar S; Sabui T; Kundu CK; Biswas A
  • Eur J Rheumatol 2017[Sep]; 4 (3): 178-83 PMID29163999show ga
  • Objective: To assess the long-term outcome of lupus nephritis in children with systemic lupus erythematosus followed up over 12 years at a tertiary care teaching hospital in Eastern India. Material and Methods: This is a retrospective observational study of the clinicopathological presentation, management, and outcome in 46 children with lupus nephritis over a period of 12 years at a tertiary teaching hospital in Eastern India. Mortality was compared between different lupus classes and therapy groups with Kaplan-Meier analysis and log-rank test Results: The incidence of lupus nephritis was 58.97% [95% confidence interval (CI) 48.06%?59.89%] with the mean age at presentation being 10.2±2.43 years (range 5.5?14.5) years. Majority belonged to class IV (30.43%), followed by class II (26.91%), class III (23.91), and class V (8.70%). Outcome analysis of children with lupus nephritis over 12 years revealed that 24 (52.17%) achieved complete remission of disease activity, 5 attained partial remission, 4 continued to have active disease, 5 developed end-stage renal disease (ESRD), and 8 died. Overall mortality thus observed was 17.39% with septicemia in the background of ESRD being the commonest cause. No significant difference in mortality was observed between different lupus nephritis classes or therapy arm groups. Conclusion: The study throws light on various aspects of lupus nephritis and their long-term outcome patterns in children from developing countries such as India.
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