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10.1002/cpt.411 http://scihub22266oqcxt.onion/10.1002/cpt.411 C5684873!5684873!27311679     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Pharmacol+Ther 2016 ; 100 (4): 380-8 Nephropedia Template TP {{tp|p=27311679|t=2016. Comparison of Genome Sequencing and Clinical Genotyping for Pharmacogenes |pdf=|usr=}}{{27311679}} gab.com Text Comparison of Genome Sequencing and Clinical Genotyping for Pharmacogenes JO: Clin Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=27311679 #FOAvip We compared whole exome sequencing (WES, n = 176 patients) and whole genome sequencing (WGS, n = 68) and clinical genotyping (DMET array-based approach) for interrogating 13 genes with Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines. We focused on 127 CPIC important variants: 103 single nucleotide variations (SNV), 21 insertion/deletions (Indel), HLA-B alleles, and two CYP2D6 structural variations. WES and WGS provided interrogation of nonoverlapping sets of 115 SNV/Indels with call rate >98%. Among 68 loci interrogated by both WES and DMET, 64 loci (94.1%, confidence interval [CI]: 85.6?98.4%) showed no discrepant genotyping calls. Among 66 loci interrogated by both WGS and DMET, 63 loci (95.5%, CI: 87.2?99.0%) showed no discrepant genotyping calls. In conclusion, even without optimization to interrogate pharmacogenetic variants, WES and WGS displayed potential to provide reliable interrogation of most pharmacogenes and further validation of genome sequencing in a clinical lab setting is warranted. Twit Text FOAVip Comparison of Genome Sequencing and Clinical Genotyping for Pharmacogenes ????Clin Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=27311679 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27311679 #FOAvip English Wikipedia <ref>{{Cite pmid|27311679}}</ref> Comparison of Genome Sequencing and Clinical Genotyping for Pharmacogenes #MMPMID27311679 Yang W; Wu G; Broeckel U; Smith C; Turner V; Haidar C; Wang S; Carter R; Karol S; Neale G; Crews K; Yang J; Mullighan C; Downing J; Evans W; Relling M Clin Pharmacol Ther 2016[Oct]; 100 (4): 380-8 PMID27311679show ga We compared whole exome sequencing (WES, n = 176 patients) and whole genome sequencing (WGS, n = 68) and clinical genotyping (DMET array-based approach) for interrogating 13 genes with Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines. We focused on 127 CPIC important variants: 103 single nucleotide variations (SNV), 21 insertion/deletions (Indel), HLA-B alleles, and two CYP2D6 structural variations. WES and WGS provided interrogation of nonoverlapping sets of 115 SNV/Indels with call rate >98%. Among 68 loci interrogated by both WES and DMET, 64 loci (94.1%, confidence interval [CI]: 85.6?98.4%) showed no discrepant genotyping calls. Among 66 loci interrogated by both WGS and DMET, 63 loci (95.5%, CI: 87.2?99.0%) showed no discrepant genotyping calls. In conclusion, even without optimization to interrogate pharmacogenetic variants, WES and WGS displayed potential to provide reliable interrogation of most pharmacogenes and further validation of genome sequencing in a clinical lab setting is warranted. äComparison of Genome Sequencing and Clinical Genotyping for Pharmacoge(epmc).pdf DeepDyve Pubget Overpricing