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10.1002/prp2.337 http://scihub22266oqcxt.onion/10.1002/prp2.337 C5684866!5684866!28805975     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pharmacol+Res+Perspect 2017 ; 5 (4): ä Nephropedia Template TP {{tp|p=28805975|t=2017. Antofine suppresses endotoxin?induced inflammation and metabolic disorder via AMP?activated protein kinase |pdf=|usr=}}{{28805975}} gab.com Text Antofine suppresses endotoxin induced inflammation and metabolic disorder via AMP activated protein kinase JO: Pharmacol Res Perspect http://www.kidney.de/pget.php?&tw=1&pmid=28805975 #FOAvip The inhibition of activated macrophages has been used to develop anti?inflammatory agents for therapeutic intervention to human diseases that cause excessive inflammatory responses. Antofine, a phenanthroindolizidine alkaloid, has a potent anti?inflammatory effect. However, the molecular mechanisms of its anti?inflammatory activity have not yet been fully detailed. In this study, we comprehensively explored the anti?inflammatory effects of antofine on endotoxin?induced inflammation in macrophages using cDNA microarray analysis, thereby elucidating the potential mechanism by which antofine suppresses inflammation. Antofine significantly suppressed the secretion of proinflammatory cytokines such as TNF? and IL?1? and the production of iNOS in LPS?activated Raw264.7 macrophage cells. In addition, antofine can suppress the expressions of several inflammation?related genes (such as ARG?1, IL1F9, IL?10, and IL?33) and extracellular matrix genes (such as TNC and HYAL1), as well as a vasopressor gene (EDN1) in activated macrophage cells, that are induced by LPS stimulation. The gene expression profiles analyzed by GeneMANIA software showed that antofine not only contributed anti?inflammatory activity but also modulated the cellular metabolism via AMPK. Furthermore, antofine also modulated the activation of AMPK and caspase?1, the key regulator in inflammasome?mediated IL?1? maturation, in activated macrophage cells. In conclusion, these data indicated that antofine potentially can not only contribute an anti?inflammatory effect but can also attenuate the metabolic disorders induced by inflammation via AMPK. Twit Text FOAVip Antofine suppresses endotoxin induced inflammation and metabolic disorder via AMP activated protein kinase ????Pharmacol Res Perspect http://www.kidney.de/pget.php?&tw=1&pmid=28805975 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28805975 #FOAvip English Wikipedia <ref>{{Cite pmid|28805975}}</ref> Antofine suppresses endotoxin?induced inflammation and metabolic disorder via AMP?activated protein kinase #MMPMID28805975 Chou S; Jung F; Yang S; Chou H; Jow G; Lin J Pharmacol Res Perspect 2017[Aug]; 5 (4): ä PMID28805975show ga The inhibition of activated macrophages has been used to develop anti?inflammatory agents for therapeutic intervention to human diseases that cause excessive inflammatory responses. Antofine, a phenanthroindolizidine alkaloid, has a potent anti?inflammatory effect. However, the molecular mechanisms of its anti?inflammatory activity have not yet been fully detailed. In this study, we comprehensively explored the anti?inflammatory effects of antofine on endotoxin?induced inflammation in macrophages using cDNA microarray analysis, thereby elucidating the potential mechanism by which antofine suppresses inflammation. Antofine significantly suppressed the secretion of proinflammatory cytokines such as TNF? and IL?1? and the production of iNOS in LPS?activated Raw264.7 macrophage cells. In addition, antofine can suppress the expressions of several inflammation?related genes (such as ARG?1, IL1F9, IL?10, and IL?33) and extracellular matrix genes (such as TNC and HYAL1), as well as a vasopressor gene (EDN1) in activated macrophage cells, that are induced by LPS stimulation. The gene expression profiles analyzed by GeneMANIA software showed that antofine not only contributed anti?inflammatory activity but also modulated the cellular metabolism via AMPK. Furthermore, antofine also modulated the activation of AMPK and caspase?1, the key regulator in inflammasome?mediated IL?1? maturation, in activated macrophage cells. In conclusion, these data indicated that antofine potentially can not only contribute an anti?inflammatory effect but can also attenuate the metabolic disorders induced by inflammation via AMPK. äAntofine suppresses endotoxin?induced inflammation and metabolic disor(epmc).pdf DeepDyve Pubget Overpricing