Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28805977
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Pharmacol+Res+Perspect
2017 ; 5
(4
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Prevention against renal damage in rats with subtotal nephrectomy by
sacubitril/valsartan (LCZ696), a dual-acting angiotensin receptor-neprilysin
inhibitor
#MMPMID28805977
Ushijima K
; Ando H
; Arakawa Y
; Aizawa K
; Suzuki C
; Shimada K
; Tsuruoka SI
; Fujimura A
Pharmacol Res Perspect
2017[Aug]; 5
(4
): ä PMID28805977
show ga
Although patients with chronic kidney disease (CKD) are at increased risk for
end-stage renal disease and cardiovascular events, adequate drug therapies for
preventing the deterioration of these conditions are still not established. This
study was undertaken to evaluate a preventive effect of an angiotensin
receptor-neprilysin inhibitor sacubitril/valsartan (LCZ696), which is converted
to sacubitril and valsartan in the body, against the progression of renal disease
in rats with subtotal nephrectomy, an animal model of human CKD. Mean survival
time after subtotal nephrectomy was about 100 days in Wistar rats with vehicle.
LCZ696-(30 mg/kg) and valsartan-(15 mg/kg) prolonged the survival of these
animals, and the effect of LCZ696 on survival was significantly greater than that
of valsartan. Renoprotective effects of LCZ696 judged by serum creatinine and
urinary protein excretions were larger than those of valsartan. Cardioprotective
effects judged by cardiac left ventricular mass, fractional shortening, and
fibrosis of LCZ696 and valsartan were not detected under the present condition.
Thus, the renoprotective effect of LCZ696 was stronger than that of valsartan in
rats with subtotal nephrectomy. This study provides the idea that, compared to
valsartan, LCZ696 is more effective for the treatment of human CKD.
free
free
free
