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2017 ; 7
(3 Suppl
): 195S-202S
Nephropedia Template TP
gab.com Text
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English Wikipedia
A Clinical Practice Guideline for the Management of Patients With Acute Spinal
Cord Injury and Central Cord Syndrome: Recommendations on the Timing (?24 Hours
Versus 24 Hours) of Decompressive Surgery
#MMPMID29164024
Fehlings MG
; Tetreault LA
; Wilson JR
; Aarabi B
; Anderson P
; Arnold PM
; Brodke DS
; Burns AS
; Chiba K
; Dettori JR
; Furlan JC
; Hawryluk G
; Holly LT
; Howley S
; Jeji T
; Kalsi-Ryan S
; Kotter M
; Kurpad S
; Marino RJ
; Martin AR
; Massicotte E
; Merli G
; Middleton JW
; Nakashima H
; Nagoshi N
; Palmieri K
; Singh A
; Skelly AC
; Tsai EC
; Vaccaro A
; Yee A
; Harrop JS
Global Spine J
2017[Sep]; 7
(3 Suppl
): 195S-202S
PMID29164024
show ga
OBJECTIVE: To develop recommendations on the timing of surgical decompression in
patients with traumatic spinal cord injury (SCI) and central cord syndrome.
METHODS: A systematic review of the literature was conducted to address key
relevant questions. A multidisciplinary guideline development group used this
information, along with their clinical expertise, to develop recommendations for
the timing of surgical decompression in patients with SCI and central cord
syndrome. Based on GRADE, a strong recommendation is worded as "we recommend,"
whereas a weak recommendation is presented as "we suggest." RESULTS: Conclusions
from the systematic review included (1) isolated studies reported statistically
significant and clinically important improvements following early decompression
at 6 months and following discharge from inpatient rehabilitation; (2) in one
study on acute central cord syndrome without instability, a marginally
significant improvement in total motor scores was reported at 6 and 12 months in
patients managed with early versus late surgery; and (3) there were no
significant differences in length of acute care/rehabilitation stay or in rates
of complications between treatment groups. Our recommendations were: "We suggest
that early surgery be considered as a treatment option in adult patients with
traumatic central cord syndrome" and "We suggest that early surgery be offered as
an option for adult acute SCI patients regardless of level." Quality of evidence
for both recommendations was considered low. CONCLUSIONS: These guidelines should
be implemented into clinical practice to improve outcomes in patients with acute
SCI and central cord syndrome by promoting standardization of care, decreasing
the heterogeneity of management strategies, and encouraging clinicians to make
evidence-informed decisions.