Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1186/s12964-017-0203-0 http://scihub22266oqcxt.onion/10.1186/s12964-017-0203-0 C5684747!5684747!29132395     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Commun+Signal 2017 ; 15 (ä): ä Nephropedia Template TP {{tp|p=29132395|t=2017. Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure |pdf=|usr=}}{{29132395}} gab.com Text Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure JO: Cell Commun Signal http://www.kidney.de/pget.php?&tw=1&pmid=29132395 #FOAvip Background: One of the most common side effects of the immunosuppressive drug tacrolimus (FK506) is the increased risk of new-onset diabetes mellitus. However, the molecular mechanisms underlying this association have not been fully clarified. Methods: We studied the effects of the therapeutic dose of tacrolimus on mitochondrial fitness in beta-cells. Results: We demonstrate that tacrolimus impairs glucose-stimulated insulin secretion (GSIS) in beta-cells through a previously unidentified mechanism. Indeed, tacrolimus causes a decrease in mitochondrial Ca2+ uptake, accompanied by altered mitochondrial respiration and reduced ATP production, eventually leading to impaired GSIS. Conclusion: Our observations individuate a new fundamental mechanism responsible for the augmented incidence of diabetes following tacrolimus treatment. Indeed, this drug alters Ca2+ fluxes in mitochondria, thereby compromising metabolism-secretion coupling in beta-cells. Twit Text FOAVip Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure ????Cell Commun Signal http://www.kidney.de/pget.php?&tw=1&pmid=29132395 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29132395 #FOAvip English Wikipedia <ref>{{Cite pmid|29132395}}</ref> Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure #MMPMID29132395 Lombardi A; Trimarco B; Iaccarino G; Santulli G Cell Commun Signal 2017[]; 15 (ä): ä PMID29132395show ga Background: One of the most common side effects of the immunosuppressive drug tacrolimus (FK506) is the increased risk of new-onset diabetes mellitus. However, the molecular mechanisms underlying this association have not been fully clarified. Methods: We studied the effects of the therapeutic dose of tacrolimus on mitochondrial fitness in beta-cells. Results: We demonstrate that tacrolimus impairs glucose-stimulated insulin secretion (GSIS) in beta-cells through a previously unidentified mechanism. Indeed, tacrolimus causes a decrease in mitochondrial Ca2+ uptake, accompanied by altered mitochondrial respiration and reduced ATP production, eventually leading to impaired GSIS. Conclusion: Our observations individuate a new fundamental mechanism responsible for the augmented incidence of diabetes following tacrolimus treatment. Indeed, this drug alters Ca2+ fluxes in mitochondria, thereby compromising metabolism-secretion coupling in beta-cells. äImpaired mitochondrial calcium uptake caused by tacrolimus underlies b(epmc).pdf DeepDyve Pubget Overpricing