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10.1038/s41467-017-01514-3 http://scihub22266oqcxt.onion/10.1038/s41467-017-01514-3 C5684212!5684212!29133867     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=29133867|t=2017. Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells |pdf=|usr=}}{{29133867}} gab.com Text Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29133867 #FOAvip Renal angiomyolipomas (AML) contain an admixture of clonal tumour cells with features of several different mesenchymal lineages, implying the existence of an unidentified AML neoplastic stem cell. Biallelic inactivation of TSC2 or TSC1 is believed to represent the driving event in these tumours. Here we show that TSC2 knockdown transforms senescence-resistant cultured mouse and human renal epithelial cells into neoplastic stem cells that serially propagate renal AML-like tumours in mice. mTOR inhibitory therapy of mouse AML allografts mimics the clinical responses of human renal AMLs. Deletion of Tsc1 in mouse renal epithelia causes differentiation in vivo into cells expressing characteristic AML markers. Human renal AML and a renal AML cell line express proximal tubule markers. We describe the first mouse models of renal AML and provide evidence that these mesenchymal tumours originate from renal proximal tubule epithelial cells, uncovering an unexpected pathological differentiation plasticity of the proximal tubule. Twit Text FOAVip Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29133867 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29133867 #FOAvip English Wikipedia <ref>{{Cite pmid|29133867}}</ref> Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells #MMPMID29133867 Gonçalves AF; Adlesic M; Brandt S; Hejhal T; Harlander S; Sommer L; Shakhova O; Wild PJ; Frew IJ Nat Commun 2017[]; 8 (ä): ä PMID29133867show ga Renal angiomyolipomas (AML) contain an admixture of clonal tumour cells with features of several different mesenchymal lineages, implying the existence of an unidentified AML neoplastic stem cell. Biallelic inactivation of TSC2 or TSC1 is believed to represent the driving event in these tumours. Here we show that TSC2 knockdown transforms senescence-resistant cultured mouse and human renal epithelial cells into neoplastic stem cells that serially propagate renal AML-like tumours in mice. mTOR inhibitory therapy of mouse AML allografts mimics the clinical responses of human renal AMLs. Deletion of Tsc1 in mouse renal epithelia causes differentiation in vivo into cells expressing characteristic AML markers. Human renal AML and a renal AML cell line express proximal tubule markers. We describe the first mouse models of renal AML and provide evidence that these mesenchymal tumours originate from renal proximal tubule epithelial cells, uncovering an unexpected pathological differentiation plasticity of the proximal tubule. äEvidence of renal angiomyolipoma neoplastic stem cells arising from re(epmc).pdf DeepDyve Pubget Overpricing