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10.1038/s41467-017-01602-4 http://scihub22266oqcxt.onion/10.1038/s41467-017-01602-4 C5684130!5684130!29133782     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=29133782|t=2017. mTOR intersects antibody-inducing signals from TACI in marginal zone B cells |pdf=|usr=}}{{29133782}} gab.com Text mTOR intersects antibody-inducing signals from TACI in marginal zone B cells JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29133782 #FOAvip Mechanistic target of rapamycin (mTOR) enhances immunity in addition to orchestrating metabolism. Here we show that mTOR coordinates immunometabolic reconfiguration of marginal zone (MZ) B cells, a pre-activated lymphocyte subset that mounts antibody responses to T-cell-independent antigens through a Toll-like receptor (TLR)-amplified pathway involving transmembrane activator and CAML interactor (TACI). This receptor interacts with mTOR via the TLR adapter MyD88. The resulting mTOR activation instigates MZ B-cell proliferation, immunoglobulin G (IgG) class switching, and plasmablast differentiation through a rapamycin-sensitive pathway that integrates metabolic and antibody-inducing transcription programs, including NF-?B. Disruption of TACI?mTOR interaction by rapamycin, truncation of the MyD88-binding domain of TACI, or B-cell-conditional mTOR deficiency interrupts TACI signaling via NF-?B and cooperation with TLRs, thereby hampering IgG production to T-cell-independent antigens but not B-cell survival. Thus, mTOR drives innate-like antibody responses by linking proximal TACI signaling events with distal immunometabolic transcription programs. Twit Text FOAVip mTOR intersects antibody-inducing signals from TACI in marginal zone B cells ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29133782 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29133782 #FOAvip English Wikipedia <ref>{{Cite pmid|29133782}}</ref> mTOR intersects antibody-inducing signals from TACI in marginal zone B cells #MMPMID29133782 Sintes J; Gentile M; Zhang S; Garcia-Carmona Y; Magri G; Cassis L; Segura-Garzón D; Ciociola A; Grasset EK; Bascones S; Comerma L; Pybus M; Lligé D; Puga I; Gutzeit C; He B; DuBois W; Crespo M; Pascual J; Mensa A; Aróstegui JI; Juan M; Yagüe J; Serrano S; Lloreta J; Meffre E; Hahne M; Cunningham-Rundles C; Mock BA; Cerutti A Nat Commun 2017[]; 8 (ä): ä PMID29133782show ga Mechanistic target of rapamycin (mTOR) enhances immunity in addition to orchestrating metabolism. Here we show that mTOR coordinates immunometabolic reconfiguration of marginal zone (MZ) B cells, a pre-activated lymphocyte subset that mounts antibody responses to T-cell-independent antigens through a Toll-like receptor (TLR)-amplified pathway involving transmembrane activator and CAML interactor (TACI). This receptor interacts with mTOR via the TLR adapter MyD88. The resulting mTOR activation instigates MZ B-cell proliferation, immunoglobulin G (IgG) class switching, and plasmablast differentiation through a rapamycin-sensitive pathway that integrates metabolic and antibody-inducing transcription programs, including NF-?B. Disruption of TACI?mTOR interaction by rapamycin, truncation of the MyD88-binding domain of TACI, or B-cell-conditional mTOR deficiency interrupts TACI signaling via NF-?B and cooperation with TLRs, thereby hampering IgG production to T-cell-independent antigens but not B-cell survival. Thus, mTOR drives innate-like antibody responses by linking proximal TACI signaling events with distal immunometabolic transcription programs. ämTOR intersects antibody-inducing signals from TACI in marginal zone B(epmc).pdf DeepDyve Pubget Overpricing