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10.3389/fimmu.2017.01509 http://scihub22266oqcxt.onion/10.3389/fimmu.2017.01509 C5684111!5684111!29170667     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=29170667|t=2017. Will a mAb-Based Immunotherapy Directed against Cancer Stem Cells Be Feasible?|pdf=|usr=}}{{29170667}} gab.com Text Will a mAb-Based Immunotherapy Directed against Cancer Stem Cells Be Feasible JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29170667 #FOAvip The cancer stem cell (CSC) hypothesis suggests that within a tumor, there is a small subpopulation of cells with stem cell properties responsible for tumor maintenance and metastasis generation. This hypothesis also implies that new antitumor drugs, rather than targeting the bulk of the tumor mass, would be more effective if they directly targeted the CSC subpopulation. The CSCs from several types of tumors have been identified with mAbs recognizing surface antigens in these cells; however, antigens specifically or exclusively expressed in the CSC population have not yet been identified. Thus, questioning the possibility of using therapeutic antibodies directed against the CSCs. Here, we review the possibilities of using antibodies directly targeting the CSCs as therapeutic agents in the form of naked antibodies, antibodies conjugated to nanoparticles, or antibody cocktails. Twit Text FOAVip Will a mAb-Based Immunotherapy Directed against Cancer Stem Cells Be Feasible ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29170667 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29170667 #FOAvip English Wikipedia <ref>{{Cite pmid|29170667}}</ref> Will a mAb-Based Immunotherapy Directed against Cancer Stem Cells Be Feasible? #MMPMID29170667 Santamaria S; Delgado M; Kremer L; Garcia-Sanz JA Front Immunol 2017[]; 8 (ä): ä PMID29170667show ga The cancer stem cell (CSC) hypothesis suggests that within a tumor, there is a small subpopulation of cells with stem cell properties responsible for tumor maintenance and metastasis generation. This hypothesis also implies that new antitumor drugs, rather than targeting the bulk of the tumor mass, would be more effective if they directly targeted the CSC subpopulation. The CSCs from several types of tumors have been identified with mAbs recognizing surface antigens in these cells; however, antigens specifically or exclusively expressed in the CSC population have not yet been identified. Thus, questioning the possibility of using therapeutic antibodies directed against the CSCs. Here, we review the possibilities of using antibodies directly targeting the CSCs as therapeutic agents in the form of naked antibodies, antibodies conjugated to nanoparticles, or antibody cocktails. äWill a mAb-Based Immunotherapy Directed against Cancer Stem Cells Be F(epmc).pdf DeepDyve Pubget Overpricing