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10.1139/bcb-2014-0093

http://scihub22266oqcxt.onion/10.1139/bcb-2014-0093
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suck abstract from ncbi


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pmid25493710      Biochem+Cell+Biol 2015 ; 93 (2): 119-27
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  • Epigenetic Contributions to the Developmental Origins of Adult Lung Disease #MMPMID25493710
  • Joss-Moore LA; Lane RH; Albertine KH
  • Biochem Cell Biol 2015[Apr]; 93 (2): 119-27 PMID25493710show ga
  • Perinatal insults, including intrauterine growth restriction, preterm birth, maternal exposure to toxins, or dietary deficiencies produce deviations in the epigenome of lung cells. Occurrence of perinatal insults often coincides with the final stages of lung development. The result of epigenome disruptions in response to perinatal insults during lung development may be long-term structural and functional impairment of the lung and development of lung disease. Understanding the contribution of epigenetic mechanisms to life-long lung disease following perinatal insults is the focus of the developmental origins of adult lung disease field. DNA methylation, histone modifications, and microRNA changes are all observed in various forms of lung disease. However, the perinatal contribution to such epigenetic mechanisms is poorly understood. Here we discuss the developmental origins of adult lung disease, the interplay between perinatal events, lung development and disease, and the role that epigenetic mechanisms play in connecting these events.
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