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2016 ; 34
(10
): 1988-97
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Effects of preterm birth and ventilation on glomerular capillary growth in the
neonatal lamb kidney
#MMPMID27428042
Sutherland MR
; Ryan D
; Dahl MJ
; Albertine KH
; Black MJ
J Hypertens
2016[Oct]; 34
(10
): 1988-97
PMID27428042
show ga
OBJECTIVES: Preterm birth is linked to the development of hypertension later in
life. This may relate to impaired glomerular capillary growth following preterm
birth. The aim of this study was to determine the effects of preterm birth,
and/or ventilation, on glomerular capillary growth in the neonatal lamb kidney.
METHODS: Four experimental groups were analysed: preterm lambs delivered at 130
days gestation (term?=?147 days) and mechanically ventilated for 3 days (preterm
ventilated: n?=?9), 133 days gestational controls (gestational control: n?=?5),
term controls, unassisted breathing for 3 days (term control: n?=?8), and term
lambs ventilated for 3 days (term ventilated: n?=?5). In perfusion-fixed kidneys,
total nephron number, average total capillary length, and surface area per renal
corpuscle were stereologically assessed, and total renal filtration surface area
(TRFSA) was calculated. RESULTS: In comparison with term controls, preterm lambs
had significantly reduced glomerular capillary length, surface area, and TRFSA,
indicative of a low renal functional capacity. Term-ventilated lambs exhibited
significantly reduced glomerular capillary length and surface area compared with
term controls, indicating that ventilation impairs glomerular capillary growth
independently of preterm birth. CONCLUSION: Impaired glomerular capillary growth
and subsequent reduced TRFSA following preterm birth may mediate the increased
predisposition to hypertension later in life.