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10.1038/cddis.2017.526 http://scihub22266oqcxt.onion/10.1038/cddis.2017.526 C5682688!5682688 !29022893     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29022893 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Dis 2017 ; 8 (10 ): e3126 Nephropedia Template TP {{tp|p=29022893 |t=2017. MYCN contributes to the malignant characteristics of erythroleukemia through EZH2-mediated epigenetic repression of p21 |pdf=|usr=}}{{29022893 }} gab.com Text MYCN contributes to the malignant characteristics of erythroleukemia through EZH2-mediated epigenetic repression of p21 JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29022893 #FOAvip MYC proto-oncogene family including c-myc and n-myc (MYCN) are critical for normal cell development and tumorigenesis. Overexpression of c-myc causes acute erythroleukemia in vivo. However, the role of MYCN in acute erythroleukemia remains poorly understood. In this study, we found that the patients with erythroleukemia showed higher expression of MYCN than normal controls. In vitro experiments, knockdown of MYCN resulted in decreased cell proliferation, elevated autonomously cell apoptosis and increased P21-mediated cell senescence. On the contrary, overexpression of MYCN obviously promoted cell proliferation, and induced erythroid differentiation block and apoptosis resistance to cytotoxic agent. Further gene microarray and functional analysis revealed that EZH2 is a target of MYCN. Knockdown of MYCN inhibited the expression of EZH2, and then activated p21 expression through removal of H3K27me3 at the p21 promoter. Overexpression of ezh2 could antagonize the p21 activation caused by MYCN knockdown. In addition, Aurora inhibitor MLN8237 inhibited the proliferation of erythroleukemia cells through repression of MYCN/EZH2 axis, whereas it minimally affected the normal hematopoietic cells. In conclusion, MYCN contributes to the malignant characteristics of erythroleukemia through EZH2-meidated epigenetic repression of p21. MYCN may serve as a therapy target for the patients with acute erythroleukemia. Twit Text FOAVip MYCN contributes to the malignant characteristics of erythroleukemia through EZH2-mediated epigenetic repression of p21 ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29022893 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29022893 #FOAvip English Wikipedia <ref>{{Cite pmid|29022893 }}</ref> MYCN contributes to the malignant characteristics of erythroleukemia through EZH2-mediated epigenetic repression of p21 #MMPMID29022893 Liu L ; Xu F ; Chang CK ; He Q ; Wu LY ; Zhang Z ; Li X Cell Death Dis 2017[Oct]; 8 (10 ): e3126 PMID29022893 show ga MYC proto-oncogene family including c-myc and n-myc (MYCN) are critical for normal cell development and tumorigenesis. Overexpression of c-myc causes acute erythroleukemia in vivo. However, the role of MYCN in acute erythroleukemia remains poorly understood. In this study, we found that the patients with erythroleukemia showed higher expression of MYCN than normal controls. In vitro experiments, knockdown of MYCN resulted in decreased cell proliferation, elevated autonomously cell apoptosis and increased P21-mediated cell senescence. On the contrary, overexpression of MYCN obviously promoted cell proliferation, and induced erythroid differentiation block and apoptosis resistance to cytotoxic agent. Further gene microarray and functional analysis revealed that EZH2 is a target of MYCN. Knockdown of MYCN inhibited the expression of EZH2, and then activated p21 expression through removal of H3K27me3 at the p21 promoter. Overexpression of ezh2 could antagonize the p21 activation caused by MYCN knockdown. In addition, Aurora inhibitor MLN8237 inhibited the proliferation of erythroleukemia cells through repression of MYCN/EZH2 axis, whereas it minimally affected the normal hematopoietic cells. In conclusion, MYCN contributes to the malignant characteristics of erythroleukemia through EZH2-meidated epigenetic repression of p21. MYCN may serve as a therapy target for the patients with acute erythroleukemia. |Apoptosis/genetics [MESH] |Aurora Kinases/antagonists & inhibitors [MESH] |Azepines/pharmacology [MESH] |Cell Differentiation/genetics [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/genetics [MESH] |Cellular Senescence/genetics [MESH] |Cyclin-Dependent Kinase Inhibitor p21/antagonists & inhibitors/*genetics/metabolism [MESH] |Enhancer of Zeste Homolog 2 Protein/*genetics/metabolism [MESH] |Enzyme Activation/drug effects [MESH] |Epigenetic Repression [MESH] |Gene Expression Regulation, Neoplastic/genetics [MESH] |Humans [MESH] |Leukemia, Erythroblastic, Acute/*pathology [MESH] |N-Myc Proto-Oncogene Protein/*genetics/metabolism [MESH] |Promoter Regions, Genetic/genetics [MESH] |Proto-Oncogene Mas [MESH]MYCN contributes to the malignant characteristics of erythroleukemia t(epmc).pdf DeepDyve Pubget Overpricing