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10.1038/cddis.2017.519 http://scihub22266oqcxt.onion/10.1038/cddis.2017.519 C5682683!5682683 !29022910     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29022910 &cmd=llinks): Failed to open stream: HTTP request failed! 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Long non-coding RNA Myd88 promotes growth and metastasis in hepatocellular carcinoma via regulating Myd88 expression through H3K27 modification |pdf=|usr=}}{{29022910 }} gab.com Text Long non-coding RNA Myd88 promotes growth and metastasis in hepatocellular carcinoma via regulating Myd88 expression through H3K27 modification JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29022910 #FOAvip Enhanced Myd88 expression has been found in various parenchymal tumors especially in hepatocellular carcinoma with little mechanism of its upregulation known. A lot of long non-coding RNAs are reported to regulate the protein-coding genes which have location association through various mechanisms. In our study we confirmed a new long non-coding RNA Myd88 aberrant upregulated in HCC located upstream of Myd88 and verified a positive regulation relationship between them indicating that Lnc-Myd88 might participate in the enhanced expression of Myd88 in HCC. The gain- and loss-of-function analysis revealed that Lnc-Myd88 could promote the proliferation and metastasis of HCC both in vitro and in vivo. In addition, ChIP assays demonstrated that Lnc-Myd88 might increase Myd88 expression through enhancing H3K27Ac in the promoter of Myd88 gene, thus resulting in the activation of both NF-?B and PI3K/AKT signal pathways. In conclusion, we proposed that Lnc-Myd88 might serve as a novel diagnosis and therapeutic target for HCC. Twit Text FOAVip Long non-coding RNA Myd88 promotes growth and metastasis in hepatocellular carcinoma via regulating Myd88 expression through H3K27 modification ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29022910 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29022910 #FOAvip English Wikipedia <ref>{{Cite pmid|29022910 }}</ref> Long non-coding RNA Myd88 promotes growth and metastasis in hepatocellular carcinoma via regulating Myd88 expression through H3K27 modification #MMPMID29022910 Xu X ; Yin Y ; Tang J ; Xie Y ; Han Z ; Zhang X ; Liu Q ; Qin X ; Huang X ; Sun B Cell Death Dis 2017[Oct]; 8 (10 ): e3124 PMID29022910 show ga Enhanced Myd88 expression has been found in various parenchymal tumors especially in hepatocellular carcinoma with little mechanism of its upregulation known. A lot of long non-coding RNAs are reported to regulate the protein-coding genes which have location association through various mechanisms. In our study we confirmed a new long non-coding RNA Myd88 aberrant upregulated in HCC located upstream of Myd88 and verified a positive regulation relationship between them indicating that Lnc-Myd88 might participate in the enhanced expression of Myd88 in HCC. The gain- and loss-of-function analysis revealed that Lnc-Myd88 could promote the proliferation and metastasis of HCC both in vitro and in vivo. In addition, ChIP assays demonstrated that Lnc-Myd88 might increase Myd88 expression through enhancing H3K27Ac in the promoter of Myd88 gene, thus resulting in the activation of both NF-?B and PI3K/AKT signal pathways. In conclusion, we proposed that Lnc-Myd88 might serve as a novel diagnosis and therapeutic target for HCC. |Animals [MESH] |Carcinoma, Hepatocellular/genetics/mortality/*pathology [MESH] |Cell Line, Tumor [MESH] |Cell Movement/genetics [MESH] |Cell Proliferation/genetics [MESH] |Gene Expression Regulation, Neoplastic/*genetics [MESH] |Hep G2 Cells [MESH] |Histones/metabolism [MESH] |Humans [MESH] |Liver Neoplasms/genetics/mortality/*pathology [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |Myeloid Differentiation Factor 88/*genetics [MESH] |NF-kappa B/genetics [MESH] |Neoplasm Invasiveness/genetics [MESH] |Neoplasm Transplantation [MESH] |Phosphatidylinositol 3-Kinases/metabolism [MESH] |Promoter Regions, Genetic/genetics [MESH] |Proto-Oncogene Proteins c-akt/metabolism [MESH] |RNA Interference [MESH] |RNA, Long Noncoding/*genetics [MESH] |RNA, Small Interfering/genetics [MESH]Long non-coding RNA Myd88 promotes growth and metastasis in hepatocell(epmc).pdf DeepDyve Pubget Overpricing