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10.1038/cddis.2017.505 http://scihub22266oqcxt.onion/10.1038/cddis.2017.505 C5682671!5682671 !29022922     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29022922 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29022922 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Dis 2017 ; 8 (10 ): e3105 Nephropedia Template TP {{tp|p=29022922 |t=2017. RANKL-mediated harmonious dialogue between fetus and mother guarantees smooth gestation by inducing decidual M2 macrophage polarization |pdf=|usr=}}{{29022922 }} gab.com Text RANKL-mediated harmonious dialogue between fetus and mother guarantees smooth gestation by inducing decidual M2 macrophage polarization JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29022922 #FOAvip Decidual macrophages (dM?) contribute to maternal-fetal tolerance. However, the mechanism of dM? differentiation during pregnancy is still largely unknown. Here, we report that receptor activator for nuclear factor-? B ligand (RANKL), secreted by human embryonic trophoblasts and maternal decidual stromal cells (DSCs), polarizes dM? toward a M2 phenotype. This polarization is mediated through activation of Akt/signal transducer and activator of transcription 6 (STAT6) signaling, which is associated with the upregulation of histone H3 lysine-27 demethylase Jmjd3 and IRF4 in dM?. Such differentiated dM? can induce a Th2 bias that promotes maternal-fetal tolerance. Impaired expression of RANKL leads to dysfunction of dM? in vivo and increased rates of fetal loss in mice. Transfer of RANK(+)M? reverses mouse fetal loss induced by M? depletion. Compared with normal pregnancy, there are abnormally low levels of RANKL/RANK in villi and decidua from miscarriage patients. These results suggest that RANKL is a pivotal regulator of maternal-fetal tolerance by licensing dM? to ensure a successful pregnancy outcome. This observation provides a scientific basis on which a potential therapeutic strategy can be targeted to prevent pregnancy loss. Twit Text FOAVip RANKL-mediated harmonious dialogue between fetus and mother guarantees smooth gestation by inducing decidual M2 macrophage polarization ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29022922 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29022922 #FOAvip English Wikipedia <ref>{{Cite pmid|29022922 }}</ref> RANKL-mediated harmonious dialogue between fetus and mother guarantees smooth gestation by inducing decidual M2 macrophage polarization #MMPMID29022922 Meng YH ; Zhou WJ ; Jin LP ; Liu LB ; Chang KK ; Mei J ; Li H ; Wang J ; Li DJ ; Li MQ Cell Death Dis 2017[Oct]; 8 (10 ): e3105 PMID29022922 show ga Decidual macrophages (dM?) contribute to maternal-fetal tolerance. However, the mechanism of dM? differentiation during pregnancy is still largely unknown. Here, we report that receptor activator for nuclear factor-? B ligand (RANKL), secreted by human embryonic trophoblasts and maternal decidual stromal cells (DSCs), polarizes dM? toward a M2 phenotype. This polarization is mediated through activation of Akt/signal transducer and activator of transcription 6 (STAT6) signaling, which is associated with the upregulation of histone H3 lysine-27 demethylase Jmjd3 and IRF4 in dM?. Such differentiated dM? can induce a Th2 bias that promotes maternal-fetal tolerance. Impaired expression of RANKL leads to dysfunction of dM? in vivo and increased rates of fetal loss in mice. Transfer of RANK(+)M? reverses mouse fetal loss induced by M? depletion. Compared with normal pregnancy, there are abnormally low levels of RANKL/RANK in villi and decidua from miscarriage patients. These results suggest that RANKL is a pivotal regulator of maternal-fetal tolerance by licensing dM? to ensure a successful pregnancy outcome. This observation provides a scientific basis on which a potential therapeutic strategy can be targeted to prevent pregnancy loss. |Abortion, Spontaneous/*pathology [MESH] |Animals [MESH] |Decidua/cytology/*immunology [MESH] |Enzyme Activation/physiology [MESH] |Female [MESH] |Humans [MESH] |Immune Tolerance/*immunology [MESH] |Interferon Regulatory Factors/biosynthesis [MESH] |Jumonji Domain-Containing Histone Demethylases/biosynthesis [MESH] |Macrophages/*immunology [MESH] |Maternal-Fetal Exchange/*immunology [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Inbred CBA [MESH] |Mice, Inbred DBA [MESH] |Pregnancy [MESH] |Proto-Oncogene Proteins c-akt/metabolism [MESH] |RANK Ligand/*metabolism [MESH] |Receptor Activator of Nuclear Factor-kappa B/*metabolism [MESH] |STAT6 Transcription Factor/metabolism [MESH] |Signal Transduction/immunology [MESH] |Stromal Cells/metabolism [MESH] |Th2 Cells/immunology [MESH]RANKL-mediated harmonious dialogue between fetus and mother guarantees(epmc).pdf DeepDyve Pubget Overpricing