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10.1038/cddis.2017.497 http://scihub22266oqcxt.onion/10.1038/cddis.2017.497 C5682663!5682663!29022923     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Dis 2017 ; 8 (10): e3107- Nephropedia Template TP {{tp|p=29022923|t=2017. Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction |pdf=|usr=}}{{29022923}} gab.com Text Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29022923 #FOAvip MicroRNAs (miRNAs) play crucial roles in the establishment of pluripotent state by controlling pluripotent network. However, the molecular mechanisms controlling miRNAs during somatic cell reprogramming remain obscure. In this study, we show Gadd45a (growth arrest and DNA-damage-inducible protein 45a) enhances reprogramming by activating miR-295. Furthermore, we show that Gadd45a binds the promoter regions of miR-295. Nuclease accessibility assay indicates that Gadd45a opens the promoter regions of miR-295. Levels of H3K9Ac and H3K27Ac on the promoter regions of miR-295 were also increased. In conclusion, our results indicate that Gadd45a relaxes the promoter regions of miR-295 and promotes the expression of miR-295 during reprogramming, implying a concise mechanism of Gadd45a and miR-290 cluster cooperation in cell-fate determination. Twit Text FOAVip Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29022923 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29022923 #FOAvip English Wikipedia <ref>{{Cite pmid|29022923}}</ref> Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction #MMPMID29022923 Li L; Chen K; Wu Y; Long Q; Zhao D; Ma B; Pei D; Liu X Cell Death Dis 2017[Oct]; 8 (10): e3107- PMID29022923show ga MicroRNAs (miRNAs) play crucial roles in the establishment of pluripotent state by controlling pluripotent network. However, the molecular mechanisms controlling miRNAs during somatic cell reprogramming remain obscure. In this study, we show Gadd45a (growth arrest and DNA-damage-inducible protein 45a) enhances reprogramming by activating miR-295. Furthermore, we show that Gadd45a binds the promoter regions of miR-295. Nuclease accessibility assay indicates that Gadd45a opens the promoter regions of miR-295. Levels of H3K9Ac and H3K27Ac on the promoter regions of miR-295 were also increased. In conclusion, our results indicate that Gadd45a relaxes the promoter regions of miR-295 and promotes the expression of miR-295 during reprogramming, implying a concise mechanism of Gadd45a and miR-290 cluster cooperation in cell-fate determination. äGadd45a opens up the promoter regions of miR-295 facilitating pluripot(epmc).pdf DeepDyve Pubget Overpricing