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10.1042/BST20160065 http://scihub22266oqcxt.onion/10.1042/BST20160065 C5682628!5682628!27911726     free     free     free       Biochem+Soc+Trans 2016 ; 44 (5): 1441-54 Nephropedia Template TP {{tp|p=27911726|t=2016. Dichotomous Roles of TGF-? in Human Cancer |pdf=|usr=}}{{27911726}} gab.com Text Dichotomous Roles of TGF- in Human Cancer JO: Biochem Soc Trans http://www.kidney.de/pget.php?&tw=1&pmid=27911726 #FOAvip Transforming growth factor-? (TGF-?) mediates/regulates numerous biological processes including embryonic development and maintenance of cellular homeostasis in a context dependent manner. Consistent with its central role in maintaining cellular homeostasis, inhibition of TGF-? signaling results in disruption of normal homeostatic processes and subsequent carcinogenesis, defining the TGF-? signaling pathway as a tumor suppressor. However, once carcinogenesis is initiated, the TGF-? signaling pathway functions to promote cancer progression. This dichotomous function of the TGF-? signaling pathway is mediated both through altered effects on the cancer cells, including via inducing epithelial to mesenchymal transition, as well as through effects on the tumor microenvironment, including via effects on angiogenesis and immunosurveillance. Current studies support inhibition of TGF-? signaling either alone, or in conjunction with anti-angiogenic therapy or immunotherapy as a promising of strategy for the treatment of human cancers. Twit Text FOAVip Dichotomous Roles of TGF- in Human Cancer ????Biochem Soc Trans http://www.kidney.de/pget.php?&tw=1&pmid=27911726 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27911726 #FOAvip English Wikipedia <ref>{{Cite pmid|27911726}}</ref> Dichotomous Roles of TGF-? in Human Cancer #MMPMID27911726 Huang JJ; Blobe GC Biochem Soc Trans 2016[Oct]; 44 (5): 1441-54 PMID27911726show ga Transforming growth factor-? (TGF-?) mediates/regulates numerous biological processes including embryonic development and maintenance of cellular homeostasis in a context dependent manner. Consistent with its central role in maintaining cellular homeostasis, inhibition of TGF-? signaling results in disruption of normal homeostatic processes and subsequent carcinogenesis, defining the TGF-? signaling pathway as a tumor suppressor. However, once carcinogenesis is initiated, the TGF-? signaling pathway functions to promote cancer progression. This dichotomous function of the TGF-? signaling pathway is mediated both through altered effects on the cancer cells, including via inducing epithelial to mesenchymal transition, as well as through effects on the tumor microenvironment, including via effects on angiogenesis and immunosurveillance. Current studies support inhibition of TGF-? signaling either alone, or in conjunction with anti-angiogenic therapy or immunotherapy as a promising of strategy for the treatment of human cancers. äDichotomous Roles of TGF-? in Human Cancer (epmc).pdf DeepDyve Pubget Overpricing