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10.3389/fimmu.2017.01479 http://scihub22266oqcxt.onion/10.3389/fimmu.2017.01479 C5682327!5682327!29167669     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=29167669|t=2017. Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages |pdf=|usr=}}{{29167669}} gab.com Text Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29167669 #FOAvip Tumor-associated macrophages (TAMs) frequently help to sustain tumor growth and mediate immune suppression in the tumor microenvironment (TME). Here, we identified a subset of iron-loaded, pro-inflammatory TAMs localized in hemorrhagic areas of the TME. The occurrence of iron-loaded TAMs (iTAMs) correlated with reduced tumor size in patients with non-small cell lung cancer. Ex vivo experiments established that TAMs exposed to hemolytic red blood cells (RBCs) were converted into pro-inflammatory macrophages capable of directly killing tumor cells. This anti-tumor effect could also be elicited via iron oxide nanoparticles. When tested in vivo, tumors injected with such iron oxide nanoparticles led to significantly smaller tumor sizes compared to controls. These results identify hemolytic RBCs and iron as novel players in the TME that repolarize TAMs to exert direct anti-tumor effector function. Thus, the delivery of iron to TAMs emerges as a simple adjuvant therapeutic strategy to promote anti-cancer immune responses. Twit Text FOAVip Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29167669 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29167669 #FOAvip English Wikipedia <ref>{{Cite pmid|29167669}}</ref> Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages #MMPMID29167669 Costa da Silva M; Breckwoldt MO; Vinchi F; Correia MP; Stojanovic A; Thielmann CM; Meister M; Muley T; Warth A; Platten M; Hentze MW; Cerwenka A; Muckenthaler MU Front Immunol 2017[]; 8 (ä): ä PMID29167669show ga Tumor-associated macrophages (TAMs) frequently help to sustain tumor growth and mediate immune suppression in the tumor microenvironment (TME). Here, we identified a subset of iron-loaded, pro-inflammatory TAMs localized in hemorrhagic areas of the TME. The occurrence of iron-loaded TAMs (iTAMs) correlated with reduced tumor size in patients with non-small cell lung cancer. Ex vivo experiments established that TAMs exposed to hemolytic red blood cells (RBCs) were converted into pro-inflammatory macrophages capable of directly killing tumor cells. This anti-tumor effect could also be elicited via iron oxide nanoparticles. When tested in vivo, tumors injected with such iron oxide nanoparticles led to significantly smaller tumor sizes compared to controls. These results identify hemolytic RBCs and iron as novel players in the TME that repolarize TAMs to exert direct anti-tumor effector function. Thus, the delivery of iron to TAMs emerges as a simple adjuvant therapeutic strategy to promote anti-cancer immune responses. äIron Induces Anti-tumor Activity in Tumor-Associated Macrophages (epmc).pdf DeepDyve Pubget Overpricing