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10.3389/fimmu.2017.01510 http://scihub22266oqcxt.onion/10.3389/fimmu.2017.01510 C5681999!5681999!29163552     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=29163552|t=2017. T Follicular Helper Cells As a New Target for Immunosuppressive Therapies |pdf=|usr=}}{{29163552}} gab.com Text T Follicular Helper Cells As a New Target for Immunosuppressive Therapies JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29163552 #FOAvip Over the past decade, antibody-mediated (humoral) rejection has been recognized as a common cause of graft dysfunction after organ transplantation and an important determinant for graft loss. In humoral alloimmunity, T follicular helper (Tfh) cells play a crucial role, because they help naïve B cells to differentiate into memory B cells and alloantibody-producing plasma cells within germinal centers. In this way, they contribute to the induction of donor-specific antibodies, which are responsible for the humoral immune response to the allograft. In this article, we provide an overview of the current knowledge on the effects of immunosuppressive therapies on Tfh cell development and function, and discuss possible new approaches to influence the activity of Tfh cells. In addition, we discuss the potential use of Tfh cells as a pharmacodynamic biomarker to improve alloimmune-risk stratification and tailoring of immunosuppression to individualize therapy after transplantation. Twit Text FOAVip T Follicular Helper Cells As a New Target for Immunosuppressive Therapies ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29163552 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29163552 #FOAvip English Wikipedia <ref>{{Cite pmid|29163552}}</ref> T Follicular Helper Cells As a New Target for Immunosuppressive Therapies #MMPMID29163552 Yan L; de Leur K; Hendriks RW; van der Laan LJW; Shi Y; Wang L; Baan CC Front Immunol 2017[]; 8 (ä): ä PMID29163552show ga Over the past decade, antibody-mediated (humoral) rejection has been recognized as a common cause of graft dysfunction after organ transplantation and an important determinant for graft loss. In humoral alloimmunity, T follicular helper (Tfh) cells play a crucial role, because they help naïve B cells to differentiate into memory B cells and alloantibody-producing plasma cells within germinal centers. In this way, they contribute to the induction of donor-specific antibodies, which are responsible for the humoral immune response to the allograft. In this article, we provide an overview of the current knowledge on the effects of immunosuppressive therapies on Tfh cell development and function, and discuss possible new approaches to influence the activity of Tfh cells. In addition, we discuss the potential use of Tfh cells as a pharmacodynamic biomarker to improve alloimmune-risk stratification and tailoring of immunosuppression to individualize therapy after transplantation. äT Follicular Helper Cells As a New Target for Immunosuppressive Therap(epmc).pdf DeepDyve Pubget Overpricing