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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Front+Pharmacol 2017 ; 8 (ä): ä Nephropedia Template TP
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NF-??: A Potential Target in the Management of Vascular Complications of Diabetes #MMPMID29163178
Suryavanshi SV; Kulkarni YA
Front Pharmacol 2017[]; 8 (ä): ä PMID29163178show ga
Diabetes is a metabolic disorder affecting large percentage of population worldwide. NF-?? plays key role in pathogenesis of vascular complications of diabetes. Persistent hyperglycemia activates NF-?? that triggers expression of various cytokines, chemokines and cell adhesion molecules. Over-expression of TNF-?, interleukins, TGF-?, Bcl2 and other pro-inflammatory proteins and pro-apoptotic genes by NF-?? is key risk factor in vascular dysfunction. NF-?? over-expression also triggers calcification of endothelial cells leading to endothelial dysfunction and further vascular complications. Inhibition of NF-?? pro-inflammatory pathway is upcoming novel target for management of vascular complications of diabetes. Various natural and synthetic inhibitors of NF-?? have been studied in management of diabetic complications. Recent preclinical and clinical studies validate NF-?? as promising target in the management of vascular complications of diabetes.