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10.3389/fphar.2017.00798

http://scihub22266oqcxt.onion/10.3389/fphar.2017.00798
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C5681994!5681994!29163178
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suck abstract from ncbi


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pmid29163178      Front+Pharmacol 2017 ; 8 (ä): ä
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  • NF-??: A Potential Target in the Management of Vascular Complications of Diabetes #MMPMID29163178
  • Suryavanshi SV; Kulkarni YA
  • Front Pharmacol 2017[]; 8 (ä): ä PMID29163178show ga
  • Diabetes is a metabolic disorder affecting large percentage of population worldwide. NF-?? plays key role in pathogenesis of vascular complications of diabetes. Persistent hyperglycemia activates NF-?? that triggers expression of various cytokines, chemokines and cell adhesion molecules. Over-expression of TNF-?, interleukins, TGF-?, Bcl2 and other pro-inflammatory proteins and pro-apoptotic genes by NF-?? is key risk factor in vascular dysfunction. NF-?? over-expression also triggers calcification of endothelial cells leading to endothelial dysfunction and further vascular complications. Inhibition of NF-?? pro-inflammatory pathway is upcoming novel target for management of vascular complications of diabetes. Various natural and synthetic inhibitors of NF-?? have been studied in management of diabetic complications. Recent preclinical and clinical studies validate NF-?? as promising target in the management of vascular complications of diabetes.
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