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10.3389/fnana.2017.00101 http://scihub22266oqcxt.onion/10.3389/fnana.2017.00101 C5681909!5681909!29163074     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Neuroanat 2017 ; 11 (ä): ä Nephropedia Template TP {{tp|p=29163074|t=2017. The Paravascular Pathway for Brain Waste Clearance: Current Understanding, Significance and Controversy |pdf=|usr=}}{{29163074}} gab.com Text The Paravascular Pathway for Brain Waste Clearance: Current Understanding, Significance and Controversy JO: Front Neuroanat http://www.kidney.de/pget.php?&tw=1&pmid=29163074 #FOAvip The paravascular pathway, also known as the ?glymphatic? pathway, is a recently described system for waste clearance in the brain. According to this model, cerebrospinal fluid (CSF) enters the paravascular spaces surrounding penetrating arteries of the brain, mixes with interstitial fluid (ISF) and solutes in the parenchyma, and exits along paravascular spaces of draining veins. Studies have shown that metabolic waste products and solutes, including proteins involved in the pathogenesis of neurodegenerative diseases such as amyloid-beta, may be cleared by this pathway. Consequently, a growing body of research has begun to explore the association between glymphatic dysfunction and various disease states. However, significant controversy exists in the literature regarding both the direction of waste clearance as well as the anatomical space in which the waste-fluid mixture is contained. Some studies have found no evidence of interstitial solute clearance along the paravascular space of veins. Rather, they demonstrate a perivascular pathway in which waste is cleared from the brain along an anatomically distinct perivascular space in a direction opposite to that of paravascular flow. Although possible explanations have been offered, none have been able to fully reconcile the discrepancies in the literature, and many questions remain. Given the therapeutic potential that a comprehensive understanding of brain waste clearance pathways might offer, further research and clarification is highly warranted. Twit Text FOAVip The Paravascular Pathway for Brain Waste Clearance: Current Understanding, Significance and Controversy ????Front Neuroanat http://www.kidney.de/pget.php?&tw=1&pmid=29163074 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29163074 #FOAvip English Wikipedia <ref>{{Cite pmid|29163074}}</ref> The Paravascular Pathway for Brain Waste Clearance: Current Understanding, Significance and Controversy #MMPMID29163074 Bacyinski A; Xu M; Wang W; Hu J Front Neuroanat 2017[]; 11 (ä): ä PMID29163074show ga The paravascular pathway, also known as the ?glymphatic? pathway, is a recently described system for waste clearance in the brain. According to this model, cerebrospinal fluid (CSF) enters the paravascular spaces surrounding penetrating arteries of the brain, mixes with interstitial fluid (ISF) and solutes in the parenchyma, and exits along paravascular spaces of draining veins. Studies have shown that metabolic waste products and solutes, including proteins involved in the pathogenesis of neurodegenerative diseases such as amyloid-beta, may be cleared by this pathway. Consequently, a growing body of research has begun to explore the association between glymphatic dysfunction and various disease states. However, significant controversy exists in the literature regarding both the direction of waste clearance as well as the anatomical space in which the waste-fluid mixture is contained. Some studies have found no evidence of interstitial solute clearance along the paravascular space of veins. Rather, they demonstrate a perivascular pathway in which waste is cleared from the brain along an anatomically distinct perivascular space in a direction opposite to that of paravascular flow. Although possible explanations have been offered, none have been able to fully reconcile the discrepancies in the literature, and many questions remain. Given the therapeutic potential that a comprehensive understanding of brain waste clearance pathways might offer, further research and clarification is highly warranted. äThe Paravascular Pathway for Brain Waste Clearance: Current Understand(epmc).pdf DeepDyve Pubget Overpricing