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10.1038/s41598-017-15285-w http://scihub22266oqcxt.onion/10.1038/s41598-017-15285-w C5681685!5681685!29127312     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=29127312|t=2017. Progesterone attenuates temporomandibular joint inflammation through inhibition of NF-?B pathway in ovariectomized rats |pdf=|usr=}}{{29127312}} gab.com Text Progesterone attenuates temporomandibular joint inflammation through inhibition of NF- B pathway in ovariectomized rats JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29127312 #FOAvip Sex hormones may contribute to the symptomatology of female-predominant temporomandibular disorders (TMDs) inflammatory pain. Pregnant women show less symptoms of TMDs than that of non-pregnant women. Whether progesterone (P4), one of the dominant sex hormones that regulates multiple biological functions, is involved in symptoms of TMDs remains to be explored. Freund?s complete adjuvant were used to induce joint inflammation. We evaluated the behavior-related and histologic effects of P4 and the expression of tumor necrosis factor (TNF)-?, interleukin (IL)-1?, and IL-6 in the synovial membrane. Primary TMJ synoviocytes were treated with TNF-? or IL-1? with the combination of P4. Progesterone receptor antagonist RU-486 were further applied. We found that P4 replacement attenuated TMJ inflammation and the nociceptive responses in a dose-dependent manner in the ovariectomized rats. Correspondingly, P4 diminished the DNA-binding activity of NF-?B and the transcription of its target genes in a dose-dependent manner in the synovial membrane of TMJ. Furthermore, P4 treatment showed decreased mRNA expression of proinflammatory cytokines, and partially reversed TNF-? and IL-1? induced transcription of proinflammatory cytokines in the primary synoviocytes. Moreover, progesterone receptor antagonist RU-486 partially reversed the effects of P4 on NF-?B pathway. In conclusion, progesterone ameliorated TMJ inflammation through inhibition of NF-?B pathway. Twit Text FOAVip Progesterone attenuates temporomandibular joint inflammation through inhibition of NF- B pathway in ovariectomized rats ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29127312 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29127312 #FOAvip English Wikipedia <ref>{{Cite pmid|29127312}}</ref> Progesterone attenuates temporomandibular joint inflammation through inhibition of NF-?B pathway in ovariectomized rats #MMPMID29127312 Xue XT; Kou XX; Li CS; Bi RY; Meng Z; Wang XD; Zhou YH; Gan YH Sci Rep 2017[]; 7 (ä): ä PMID29127312show ga Sex hormones may contribute to the symptomatology of female-predominant temporomandibular disorders (TMDs) inflammatory pain. Pregnant women show less symptoms of TMDs than that of non-pregnant women. Whether progesterone (P4), one of the dominant sex hormones that regulates multiple biological functions, is involved in symptoms of TMDs remains to be explored. Freund?s complete adjuvant were used to induce joint inflammation. We evaluated the behavior-related and histologic effects of P4 and the expression of tumor necrosis factor (TNF)-?, interleukin (IL)-1?, and IL-6 in the synovial membrane. Primary TMJ synoviocytes were treated with TNF-? or IL-1? with the combination of P4. Progesterone receptor antagonist RU-486 were further applied. We found that P4 replacement attenuated TMJ inflammation and the nociceptive responses in a dose-dependent manner in the ovariectomized rats. Correspondingly, P4 diminished the DNA-binding activity of NF-?B and the transcription of its target genes in a dose-dependent manner in the synovial membrane of TMJ. Furthermore, P4 treatment showed decreased mRNA expression of proinflammatory cytokines, and partially reversed TNF-? and IL-1? induced transcription of proinflammatory cytokines in the primary synoviocytes. Moreover, progesterone receptor antagonist RU-486 partially reversed the effects of P4 on NF-?B pathway. In conclusion, progesterone ameliorated TMJ inflammation through inhibition of NF-?B pathway. äProgesterone attenuates temporomandibular joint inflammation through i(epmc).pdf DeepDyve Pubget Overpricing