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2017 ; 8
(ä): 1450
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The Injury-Related Activation of Hedgehog Signaling Pathway Modulates the
Repair-Associated Inflammation in Liver Fibrosis
#MMPMID29163520
Shen X
; Peng Y
; Li H
Front Immunol
2017[]; 8
(ä): 1450
PMID29163520
show ga
Liver fibrosis is a wound healing response initiated by inflammation responding
for different iterative parenchymal damages caused by diverse etiologies. Immune
cells, which exert their ability of either inducing injury or promoting repair,
have been regarded as crucial participants in the fibrogenic response. A
characteristic feature of the fibrotic microenvironment associated with chronic
liver injury is aberrant activation of hedgehog (Hh) signaling pathway. Growing
evidence from a number of different studies in vivo and in vitro has indicated
that immune-mediated events involved in liver fibrogenesis are regulated by Hh
signaling pathway. In this review, we emphasize the impacts of injury-activated
Hh signaling on liver fibrogenesis through modulating repair-related inflammation
and focus on the regulatory action of aberrant Hh signaling on repair-related
inflammatory responses mediated by hepatic classical and non-classical immune
cell populations in the progression of liver fibrosis. Moreover, we also assess
the potentiality of Hh pathway inhibitors as good candidates for anti-fibrotic
therapeutic agents because of their immune regulation actions for fibrogenic
liver repair. The identification of immune-modulatory mechanisms of Hh signaling
pathway underlying the fibrotic process of chronic liver diseases might provide a
basis for Hh-centered therapeutic strategies for liver fibrosis.