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10.1080/19420862.2017.1367074 http://scihub22266oqcxt.onion/10.1080/19420862.2017.1367074 C5680800!5680800!28812955     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       MAbs 2017 ; 9 (8): 1231-52 Nephropedia Template TP {{tp|p=28812955|t=2017. IgG cooperativity ? Is there allostery? Implications for antibody functions and therapeutic antibody development |pdf=|usr=}}{{28812955}} gab.com Text IgG cooperativity Is there allostery Implications for antibody functions and therapeutic antibody development JO: MAbs http://www.kidney.de/pget.php?&tw=1&pmid=28812955 #FOAvip A central dogma in immunology is that an antibody's in vivo functionality is mediated by 2 independent events: antigen binding by the variable (V) region, followed by effector activation by the constant (C) region. However, this view has recently been challenged by reports suggesting allostery exists between the 2 regions, triggered by conformational changes or configurational differences. The possibility of allosteric signals propagating through the IgG domains complicates our understanding of the antibody structure-function relationship, and challenges the current subclass selection process in therapeutic antibody design. Here we review the types of cooperativity in IgG molecules by examining evidence for and against allosteric cooperativity in both Fab and Fc domains and the characteristics of associative cooperativity in effector system activation. We investigate the origin and the mechanism of allostery with an emphasis on the C-region-mediated effects on both V and C region interactions, and discuss its implications in biological functions. While available research does not support the existence of antigen-induced conformational allosteric cooperativity in IgGs, there is substantial evidence for configurational allostery due to glycosylation and sequence variations. Twit Text FOAVip IgG cooperativity Is there allostery Implications for antibody functions and therapeutic antibody development ????MAbs http://www.kidney.de/pget.php?&tw=1&pmid=28812955 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28812955 #FOAvip English Wikipedia <ref>{{Cite pmid|28812955}}</ref> IgG cooperativity ? Is there allostery? Implications for antibody functions and therapeutic antibody development #MMPMID28812955 Yang D; Kroe-Barrett R; Singh S; Roberts CJ; Laue TM MAbs 2017[Nov]; 9 (8): 1231-52 PMID28812955show ga A central dogma in immunology is that an antibody's in vivo functionality is mediated by 2 independent events: antigen binding by the variable (V) region, followed by effector activation by the constant (C) region. However, this view has recently been challenged by reports suggesting allostery exists between the 2 regions, triggered by conformational changes or configurational differences. The possibility of allosteric signals propagating through the IgG domains complicates our understanding of the antibody structure-function relationship, and challenges the current subclass selection process in therapeutic antibody design. Here we review the types of cooperativity in IgG molecules by examining evidence for and against allosteric cooperativity in both Fab and Fc domains and the characteristics of associative cooperativity in effector system activation. We investigate the origin and the mechanism of allostery with an emphasis on the C-region-mediated effects on both V and C region interactions, and discuss its implications in biological functions. While available research does not support the existence of antigen-induced conformational allosteric cooperativity in IgGs, there is substantial evidence for configurational allostery due to glycosylation and sequence variations. äIgG cooperativity ? Is there allostery? Implications for antibody func(epmc).pdf DeepDyve Pubget Overpricing