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10.1080/21541248.2016.1215656 http://scihub22266oqcxt.onion/10.1080/21541248.2016.1215656 C5680677!5680677!27449543     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Small+GTPases 2017 ; 8 (4): 233-6 Nephropedia Template TP {{tp|p=27449543|t=2017. The mystery of oncogenic KRAS: Lessons from studying its wild-type counter part |pdf=|usr=}}{{27449543}} gab.com Text The mystery of oncogenic KRAS: Lessons from studying its wild-type counter part JO: Small GTPases http://www.kidney.de/pget.php?&tw=1&pmid=27449543 #FOAvip Using conditional knock-in mouse models, we and others have shown that despite the very high sequence identity between Nras and Kras proteins, oncogenic Kras displays a much stronger leukemogenic activity than oncogenic Nras in vivo. In this manuscript, we will summarize our recent work of characterizing wild-type Kras function in adult hematopoiesis and in oncogenic Kras-induced leukemogenesis. We attribute the strong leukemogenic activity of oncogenic Kras to 2 unique aspects of Kras signaling. First, Kras is required in mediating cell type- and cytokine-specific ERK1/2 signaling. Second, oncogenic Kras, but not oncogenic Nras, induces hyperactivation of wild-type Ras, which significantly enhances Ras signaling in vivo. We will also discuss a possible mechanism that mediates oncogenic Kras-evoked hyperactivation of wild-type Ras and a potential approach to down-regulate oncogenic Kras signaling. Twit Text FOAVip The mystery of oncogenic KRAS: Lessons from studying its wild-type counter part ????Small GTPases http://www.kidney.de/pget.php?&tw=1&pmid=27449543 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27449543 #FOAvip English Wikipedia <ref>{{Cite pmid|27449543}}</ref> The mystery of oncogenic KRAS: Lessons from studying its wild-type counter part #MMPMID27449543 Chang YI; Damnernsawad A; Kong G; You X; Wang D; Zhang J Small GTPases 2017[]; 8 (4): 233-6 PMID27449543show ga Using conditional knock-in mouse models, we and others have shown that despite the very high sequence identity between Nras and Kras proteins, oncogenic Kras displays a much stronger leukemogenic activity than oncogenic Nras in vivo. In this manuscript, we will summarize our recent work of characterizing wild-type Kras function in adult hematopoiesis and in oncogenic Kras-induced leukemogenesis. We attribute the strong leukemogenic activity of oncogenic Kras to 2 unique aspects of Kras signaling. First, Kras is required in mediating cell type- and cytokine-specific ERK1/2 signaling. Second, oncogenic Kras, but not oncogenic Nras, induces hyperactivation of wild-type Ras, which significantly enhances Ras signaling in vivo. We will also discuss a possible mechanism that mediates oncogenic Kras-evoked hyperactivation of wild-type Ras and a potential approach to down-regulate oncogenic Kras signaling. äThe mystery of oncogenic KRAS: Lessons from studying its wild-type cou(epmc).pdf DeepDyve Pubget Overpricing