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10.1080/21541248.2016.1215657 http://scihub22266oqcxt.onion/10.1080/21541248.2016.1215657 C5680673!5680673 !27715449     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27715449 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Small+GTPases 2017 ; 8 (4 ): 237-244 Nephropedia Template TP {{tp|p=27715449 |t=2017. Cdc42 in actin dynamics: An ordered pathway governed by complex equilibria and directional effector handover |pdf=|usr=}}{{27715449 }} gab.com Text Cdc42 in actin dynamics: An ordered pathway governed by complex equilibria and directional effector handover JO: Small GTPases http://www.kidney.de/pget.php?&tw=1&pmid=27715449 #FOAvip The small GTPase, Cdc42, is a key regulator of actin dynamics, functioning to connect multiple signals to actin polymerization through effector proteins of the Wiskott-Aldrich syndrome protein (WASP) and Transducer of Cdc42-dependent actin assembly (TOCA) families. WASP family members serve to couple Cdc42 with the actin nucleator, the Arp2/3 complex, via direct interactions. The regulation of these proteins in the context of actin dynamics has been extensively studied. Studies on the TOCA family, however, are more limited and relatively little is known about their roles and regulation. In this commentary we highlight new structural and biophysical insight into the involvement of TOCA proteins in the pathway of Cdc42-dependent actin dynamics. We discuss the biological implications of the low affinity interactions between the TOCA family and Cdc42, as well as probing the sequential binding of TOCA1 and the WASP homolog, N-WASP, to Cdc42. We place our current research in the context of the wealth of biophysical, structural and functional data from earlier studies pertaining to the Cdc42/N-WASP/Arp2/3 pathway of actin polymerization. Finally, we describe the molecular basis for a sequential G protein-effector handover from TOCA1 to N-WASP. Twit Text FOAVip Cdc42 in actin dynamics: An ordered pathway governed by complex equilibria and directional effector handover ????Small GTPases http://www.kidney.de/pget.php?&tw=1&pmid=27715449 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27715449 #FOAvip English Wikipedia <ref>{{Cite pmid|27715449 }}</ref> Cdc42 in actin dynamics: An ordered pathway governed by complex equilibria and directional effector handover #MMPMID27715449 Watson JR ; Owen D ; Mott HR Small GTPases 2017[Oct]; 8 (4 ): 237-244 PMID27715449 show ga The small GTPase, Cdc42, is a key regulator of actin dynamics, functioning to connect multiple signals to actin polymerization through effector proteins of the Wiskott-Aldrich syndrome protein (WASP) and Transducer of Cdc42-dependent actin assembly (TOCA) families. WASP family members serve to couple Cdc42 with the actin nucleator, the Arp2/3 complex, via direct interactions. The regulation of these proteins in the context of actin dynamics has been extensively studied. Studies on the TOCA family, however, are more limited and relatively little is known about their roles and regulation. In this commentary we highlight new structural and biophysical insight into the involvement of TOCA proteins in the pathway of Cdc42-dependent actin dynamics. We discuss the biological implications of the low affinity interactions between the TOCA family and Cdc42, as well as probing the sequential binding of TOCA1 and the WASP homolog, N-WASP, to Cdc42. We place our current research in the context of the wealth of biophysical, structural and functional data from earlier studies pertaining to the Cdc42/N-WASP/Arp2/3 pathway of actin polymerization. Finally, we describe the molecular basis for a sequential G protein-effector handover from TOCA1 to N-WASP. |Actins/*metabolism [MESH] |Animals [MESH] |Humans [MESH]Cdc42 in actin dynamics: An ordered pathway governed by complex equili(epmc).pdf DeepDyve Pubget Overpricing