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10.1038/cddis.2017.464

http://scihub22266oqcxt.onion/10.1038/cddis.2017.464
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C5680586!5680586!28981093
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suck abstract from ncbi


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pmid28981093      Cell+Death+Dis 2017 ; 8 (10): e3073-
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  • Long non-coding RNAs involved in autophagy regulation #MMPMID28981093
  • Yang L; Wang H; Shen Q; Feng L; Jin H
  • Cell Death Dis 2017[Oct]; 8 (10): e3073- PMID28981093show ga
  • Autophagy degrades non-functioning or damaged proteins and organelles to maintain cellular homeostasis in a physiological or pathological context. Autophagy can be protective or detrimental, depending on its activation status and other conditions. Therefore, autophagy has a crucial role in a myriad of pathophysiological processes. From the perspective of autophagy-related (ATG) genes, the molecular dissection of autophagy process and the regulation of its level have been largely unraveled. However, the discovery of long non-coding RNAs (lncRNAs) provides a new paradigm of gene regulation in almost all important biological processes, including autophagy. In this review, we highlight recent advances in autophagy-associated lncRNAs and their specific autophagic targets, as well as their relevance to human diseases such as cancer, cardiovascular disease, diabetes and cerebral ischemic stroke.
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