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10.1038/jhh.2017.61 http://scihub22266oqcxt.onion/10.1038/jhh.2017.61 C5680413!5680413!29115294     free     free     free       J+Hum+Hypertens 2017 ; 31 (12): 782-6 Nephropedia Template TP {{tp|p=29115294|t=2017. Placental growth factor and pre-eclampsia |pdf=|usr=}}{{29115294}} gab.com Text Placental growth factor and pre-eclampsia JO: J Hum Hypertens http://www.kidney.de/pget.php?&tw=1&pmid=29115294 #FOAvip Placental growth factor (PlGF) is an increasingly important molecule in the prediction, diagnosis and treatment of pre-eclampsia. It has pro-angiogenic effects on the feto-placental circulation and supports trophoblast growth. Mechanisms by which PlGF expression is regulated continue to be investigated. Low circulating PlGF precedes the manifestation of clinical disease in pre-eclamptic pregnancies and intrauterine growth restriction. This suggests that low PlGF is a marker of abnormal placentation, but it remains uncertain whether this is a cause or consequence. Prediction of pre-eclampsia using PlGF is promising and may assist in the targeting of resources to women at highest risk of adverse pregnancy outcomes. Promisingly, experimental animal models of pre-eclampsia have been successfully treated with supplemental PlGF. Treatment of pre-eclampsia with PlGF is a potential therapeutic option requiring further exploration. This review focuses specifically on the role of PlGF in normal and pathological placental development and in the clinical management of pre-eclampsia. Twit Text FOAVip Placental growth factor and pre-eclampsia ????J Hum Hypertens http://www.kidney.de/pget.php?&tw=1&pmid=29115294 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29115294 #FOAvip English Wikipedia <ref>{{Cite pmid|29115294}}</ref> Placental growth factor and pre-eclampsia #MMPMID29115294 Chau K; Hennessy A; Makris A J Hum Hypertens 2017[Dec]; 31 (12): 782-6 PMID29115294show ga Placental growth factor (PlGF) is an increasingly important molecule in the prediction, diagnosis and treatment of pre-eclampsia. It has pro-angiogenic effects on the feto-placental circulation and supports trophoblast growth. Mechanisms by which PlGF expression is regulated continue to be investigated. Low circulating PlGF precedes the manifestation of clinical disease in pre-eclamptic pregnancies and intrauterine growth restriction. This suggests that low PlGF is a marker of abnormal placentation, but it remains uncertain whether this is a cause or consequence. Prediction of pre-eclampsia using PlGF is promising and may assist in the targeting of resources to women at highest risk of adverse pregnancy outcomes. Promisingly, experimental animal models of pre-eclampsia have been successfully treated with supplemental PlGF. Treatment of pre-eclampsia with PlGF is a potential therapeutic option requiring further exploration. This review focuses specifically on the role of PlGF in normal and pathological placental development and in the clinical management of pre-eclampsia. äPlacental growth factor and pre-eclampsia (epmc).pdf DeepDyve Pubget Overpricing