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2017 ; 7
(1
): 15119
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Association of long noncoding RNAs expression levels and their gene polymorphisms
with systemic lupus erythematosus
#MMPMID29123179
Li J
; Wu GC
; Zhang TP
; Yang XK
; Chen SS
; Li LJ
; Xu SZ
; Lv TT
; Leng RX
; Pan HF
; Ye DQ
Sci Rep
2017[Nov]; 7
(1
): 15119
PMID29123179
show ga
Increasing evidence has demonstrated the association between long noncoding RNAs
(lncRNAs) and multiple autoimmune diseases. To explore four lncRNAs (GAS5,
lnc-DC, linc0597 and linc0949) expression levels and gene polymorphisms in
systemic lupus erythematosus (SLE), a two stage design was applied. In the first
stage, 85 SLE patients and 71 healthy controls were enrolled to investigate the
lncRNAs expression levels. Then, 1260 SLE patients and 1231 healthy controls were
included to detect the single nucleotide polymorphisms (SNPs) in the
differentially expressed lncRNAs identified in the first stage. Linc0597, lnc-DC
and GAS5 expression levels were significantly lower in SLE patients than healthy
controls (P?0.001, P?0.001, P?=?0.003 respectively). Association of five SNPs
(rs10515177, rs2070107, rs2632516, rs2877877, rs2067079) with SLE risk were
analyzed. No significant association was observed between these gene
polymorphisms and susceptibility to SLE (all P?>?0.010), and we did not find
significant association between any genotypes at five SNPs and their respective
lncRNAs expression in SLE (all P?>?0.010). In summary, the expression levels of
linc0597, lnc-DC and GAS5 are decreased in SLE patients, but their gene
polymorphisms are not associated with SLE risk, and do not influence their
expression levels.