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10.1038/s41598-017-15583-3 http://scihub22266oqcxt.onion/10.1038/s41598-017-15583-3 C5680268!5680268!29123197     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=29123197|t=2017. A Microdevice Platform Recapitulating Hypoxic Tumor Microenvironments |pdf=|usr=}}{{29123197}} gab.com Text A Microdevice Platform Recapitulating Hypoxic Tumor Microenvironments JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29123197 #FOAvip Hypoxia plays a central role in cancer progression and resistance to therapy. We have engineered a microdevice platform to recapitulate the intratumor oxygen gradients that drive the heterogeneous hypoxic landscapes in solid tumors. Our design features a ?tumor section?-like culture by incorporating a cell layer between two diffusion barriers, where an oxygen gradient is established by cellular metabolism and physical constraints. We confirmed the oxygen gradient by numerical simulation and imaging-based oxygen sensor measurement. We also demonstrated spatially-resolved hypoxic signaling in cancer cells through immunostaining, gene expression assay, and hypoxia-targeted drug treatment. Our platform can accurately generate and control oxygen gradients, eliminates complex microfluidic handling, allows for incorporation of additional tumor components, and is compatible with high-content imaging and high-throughput applications. It is well suited for understanding hypoxia-mediated mechanisms in cancer disease and other biological processes, and discovery of new therapeutics. Twit Text FOAVip A Microdevice Platform Recapitulating Hypoxic Tumor Microenvironments ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29123197 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29123197 #FOAvip English Wikipedia <ref>{{Cite pmid|29123197}}</ref> A Microdevice Platform Recapitulating Hypoxic Tumor Microenvironments #MMPMID29123197 Ando Y; Ta HP; Yen DP; Lee SS; Raola S; Shen K Sci Rep 2017[]; 7 (ä): ä PMID29123197show ga Hypoxia plays a central role in cancer progression and resistance to therapy. We have engineered a microdevice platform to recapitulate the intratumor oxygen gradients that drive the heterogeneous hypoxic landscapes in solid tumors. Our design features a ?tumor section?-like culture by incorporating a cell layer between two diffusion barriers, where an oxygen gradient is established by cellular metabolism and physical constraints. We confirmed the oxygen gradient by numerical simulation and imaging-based oxygen sensor measurement. We also demonstrated spatially-resolved hypoxic signaling in cancer cells through immunostaining, gene expression assay, and hypoxia-targeted drug treatment. Our platform can accurately generate and control oxygen gradients, eliminates complex microfluidic handling, allows for incorporation of additional tumor components, and is compatible with high-content imaging and high-throughput applications. It is well suited for understanding hypoxia-mediated mechanisms in cancer disease and other biological processes, and discovery of new therapeutics. äA Microdevice Platform Recapitulating Hypoxic Tumor Microenvironments (epmc).pdf DeepDyve Pubget Overpricing