Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41467-017-01385-8 http://scihub22266oqcxt.onion/10.1038/s41467-017-01385-8 C5680234!5680234 !29123084     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29123084 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29123084 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (1 ): 1395 Nephropedia Template TP {{tp|p=29123084 |t=2017. Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent |pdf=|usr=}}{{29123084 }} gab.com Text Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29123084 #FOAvip Interleukin-12 (IL-12) has emerged as one of the most potent agents for anti-tumor immunotherapy. However, potentially lethal toxicity associated with systemic administration of IL-12 precludes its clinical application. Here we redesign the molecule in such a way that its anti-tumor efficacy is not compromised, but toxic effects are eliminated. Deletion of the N-terminal signal peptide of IL-12 can effect such a change by preventing IL-12 secretion from cells. We use a newly designed tumor-targeted oncolytic adenovirus (Ad-TD) to deliver non-secreting (ns) IL-12 to tumor cells and examine the therapeutic and toxic effects in Syrian hamster models of pancreatic cancer (PaCa). Strikingly, intraperitoneal delivery of Ad-TD-nsIL-12 significantly enhanced survival of animals with orthotopic PaCa and cured peritoneally disseminated PaCa with no toxic side effects, in contrast to the treatment with Ad-TD expressing unmodified IL-12. These findings offer renewed hope for development of IL-12-based treatments for cancer. Twit Text FOAVip Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29123084 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29123084 #FOAvip English Wikipedia <ref>{{Cite pmid|29123084 }}</ref> Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent #MMPMID29123084 Wang P ; Li X ; Wang J ; Gao D ; Li Y ; Li H ; Chu Y ; Zhang Z ; Liu H ; Jiang G ; Cheng Z ; Wang S ; Dong J ; Feng B ; Chard LS ; Lemoine NR ; Wang Y Nat Commun 2017[Nov]; 8 (1 ): 1395 PMID29123084 show ga Interleukin-12 (IL-12) has emerged as one of the most potent agents for anti-tumor immunotherapy. However, potentially lethal toxicity associated with systemic administration of IL-12 precludes its clinical application. Here we redesign the molecule in such a way that its anti-tumor efficacy is not compromised, but toxic effects are eliminated. Deletion of the N-terminal signal peptide of IL-12 can effect such a change by preventing IL-12 secretion from cells. We use a newly designed tumor-targeted oncolytic adenovirus (Ad-TD) to deliver non-secreting (ns) IL-12 to tumor cells and examine the therapeutic and toxic effects in Syrian hamster models of pancreatic cancer (PaCa). Strikingly, intraperitoneal delivery of Ad-TD-nsIL-12 significantly enhanced survival of animals with orthotopic PaCa and cured peritoneally disseminated PaCa with no toxic side effects, in contrast to the treatment with Ad-TD expressing unmodified IL-12. These findings offer renewed hope for development of IL-12-based treatments for cancer. |Adenoviridae/genetics [MESH] |Animals [MESH] |Antineoplastic Agents/adverse effects/chemistry/*pharmacology [MESH] |CD8-Positive T-Lymphocytes/immunology [MESH] |Cell Line, Tumor [MESH] |Cricetinae [MESH] |Disease Models, Animal [MESH] |Female [MESH] |Gene Transfer Techniques [MESH] |Humans [MESH] |Immunotherapy/*methods [MESH] |Interleukin-12/adverse effects/chemistry/*immunology/*pharmacology [MESH] |Oncolytic Virotherapy/*methods [MESH] |Oncolytic Viruses/*genetics [MESH] |Pancreatic Neoplasms/*drug therapy/pathology [MESH]Re-designing Interleukin-12 to enhance its safety and potential as an (epmc).pdf DeepDyve Pubget Overpricing