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10.1038/s41467-017-01567-4 http://scihub22266oqcxt.onion/10.1038/s41467-017-01567-4 C5680233!5680233 !29123114     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29123114 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (1 ): 1394 Nephropedia Template TP {{tp|p=29123114 |t=2017. Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1 |pdf=|usr=}}{{29123114 }} gab.com Text Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1 JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29123114 #FOAvip Amino acid-dependent activation of the mechanistic target of rapamycin complex 1 (mTORC1) is mediated by Rag GTPases, which are recruited to the lysosome by the Ragulator complex consisting of p18, MP1, p14, HBXIP and C7orf59; however, the molecular mechanism is elusive. Here, we report the crystal structure of Ragulator, in which p18 wraps around the MP1-p14 and C7orf59-HBXIP heterodimers and the interactions of p18 with MP1, C7orf59, and HBXIP are essential for the assembly of Ragulator. There are two binding sites for the Roadblock domains of Rag GTPases: helix ?1 of p18 and the two helices side of MP1-p14. The interaction of Ragulator with Rag GTPases is required for their cellular co-localization and can be competitively inhibited by C17orf59. Collectively, our data indicate that Ragulator functions as a scaffold to recruit Rag GTPases to lysosomal membrane in mTORC1 signaling. Twit Text FOAVip Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1 ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29123114 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29123114 #FOAvip English Wikipedia <ref>{{Cite pmid|29123114 }}</ref> Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1 #MMPMID29123114 Zhang T ; Wang R ; Wang Z ; Wang X ; Wang F ; Ding J Nat Commun 2017[Nov]; 8 (1 ): 1394 PMID29123114 show ga Amino acid-dependent activation of the mechanistic target of rapamycin complex 1 (mTORC1) is mediated by Rag GTPases, which are recruited to the lysosome by the Ragulator complex consisting of p18, MP1, p14, HBXIP and C7orf59; however, the molecular mechanism is elusive. Here, we report the crystal structure of Ragulator, in which p18 wraps around the MP1-p14 and C7orf59-HBXIP heterodimers and the interactions of p18 with MP1, C7orf59, and HBXIP are essential for the assembly of Ragulator. There are two binding sites for the Roadblock domains of Rag GTPases: helix ?1 of p18 and the two helices side of MP1-p14. The interaction of Ragulator with Rag GTPases is required for their cellular co-localization and can be competitively inhibited by C17orf59. Collectively, our data indicate that Ragulator functions as a scaffold to recruit Rag GTPases to lysosomal membrane in mTORC1 signaling. |Adaptor Proteins, Signal Transducing/metabolism [MESH] |Binding Sites [MESH] |Cell Line [MESH] |Cyclin-Dependent Kinase Inhibitor p18/metabolism [MESH] |Guanine Nucleotide Exchange Factors/metabolism [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Intracellular Membranes/*metabolism [MESH] |Lysosomes/*metabolism [MESH] |Mechanistic Target of Rapamycin Complex 1/*metabolism [MESH] |Membrane Proteins/*metabolism [MESH] |Monomeric GTP-Binding Proteins/*metabolism [MESH] |Protein Binding [MESH] |Protein Structure, Secondary/physiology [MESH]Structural basis for Ragulator functioning as a scaffold in membrane-a(epmc).pdf DeepDyve Pubget Overpricing