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10.1038/s41598-017-15003-6 http://scihub22266oqcxt.onion/10.1038/s41598-017-15003-6 C5680231!5680231!29123177     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=29123177|t=2017. Liprotides kill cancer cells by disrupting the plasma membrane |pdf=|usr=}}{{29123177}} gab.com Text Liprotides kill cancer cells by disrupting the plasma membrane JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29123177 #FOAvip HAMLET (human ?-lactalbumin made lethal to tumour cells) is a complex of ?-lactalbumin (aLA) and oleic acid (OA) which kills transformed cells, while leaving fully differentiated cells largely unaffected. Other protein-lipid complexes show similar anti-cancer potential. We call such complexes liprotides. The cellular impact of liprotides, while intensely investigated, remains unresolved. To address this, we report on the cell-killing mechanisms of liprotides prepared by incubating aLA with OA for 1?h at 20 or 80?°C (lip20 and lip80, respectively). The liprotides showed similar cytotoxicity against MCF7 cells, though lip80 acts more slowly, possibly due to intermolecular disulphide bonds formed during preparation. Liprotides are known to increase the fluidity of a membrane and transfer OA to vesicles, prompting us to focus on the effect of liprotides on the cell membrane. Extracellular Ca2+ influx is important for activation of the plasma membrane repair system, and we found that removal of Ca2+ from the medium enhanced the liprotides? killing effect. Liprotide cytotoxicity was also increased by knockdown of Annexin A6 (ANXA6), a protein involved in plasma membrane repair. We conclude that MCF7 cells counteract liprotide-induced membrane permeabilization by activating their plasma membrane repair system, which is triggered by extracellular Ca2+ and involves ANXA6. Twit Text FOAVip Liprotides kill cancer cells by disrupting the plasma membrane ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29123177 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29123177 #FOAvip English Wikipedia <ref>{{Cite pmid|29123177}}</ref> Liprotides kill cancer cells by disrupting the plasma membrane #MMPMID29123177 Frislev HS; Boye TL; Nylandsted J; Otzen D Sci Rep 2017[]; 7 (ä): ä PMID29123177show ga HAMLET (human ?-lactalbumin made lethal to tumour cells) is a complex of ?-lactalbumin (aLA) and oleic acid (OA) which kills transformed cells, while leaving fully differentiated cells largely unaffected. Other protein-lipid complexes show similar anti-cancer potential. We call such complexes liprotides. The cellular impact of liprotides, while intensely investigated, remains unresolved. To address this, we report on the cell-killing mechanisms of liprotides prepared by incubating aLA with OA for 1?h at 20 or 80?°C (lip20 and lip80, respectively). The liprotides showed similar cytotoxicity against MCF7 cells, though lip80 acts more slowly, possibly due to intermolecular disulphide bonds formed during preparation. Liprotides are known to increase the fluidity of a membrane and transfer OA to vesicles, prompting us to focus on the effect of liprotides on the cell membrane. Extracellular Ca2+ influx is important for activation of the plasma membrane repair system, and we found that removal of Ca2+ from the medium enhanced the liprotides? killing effect. Liprotide cytotoxicity was also increased by knockdown of Annexin A6 (ANXA6), a protein involved in plasma membrane repair. We conclude that MCF7 cells counteract liprotide-induced membrane permeabilization by activating their plasma membrane repair system, which is triggered by extracellular Ca2+ and involves ANXA6. äLiprotides kill cancer cells by disrupting the plasma membrane (epmc).pdf DeepDyve Pubget Overpricing