Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/nm.4415 http://scihub22266oqcxt.onion/10.1038/nm.4415 C5679732!5679732!29035367     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Med 2017 ; 23 (11): 1352-61 Nephropedia Template TP {{tp|p=29035367|t=2017. Targeting Glioma Stem Cells through Combined BMI1 and EZH2 Inhibition |pdf=|usr=}}{{29035367}} gab.com Text Targeting Glioma Stem Cells through Combined BMI1 and EZH2 Inhibition JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=29035367 #FOAvip Glioblastomas are lethal cancers defined by angiogenesis and pseudopalisading necrosis. Here, we demonstrate that these histological features are associated with distinct transcriptional programs, with vascular regions showing a proneural profile and hypoxic regions a mesenchymal pattern. As these regions harbor glioma stem cells (GSCs), we investigated the epigenetic regulation of these two niches. Proneural, perivascular GSCs activated EZH2, whereas mesenchymal GSCs in hypoxic regions expressed BMI1 protein, which promoted cellular survival under stress, due to downregulation of the E3 ligase, RNF144A. Using both genetic and pharmacologic inhibition, we found that proneural GSCs are preferentially sensitive to EZH2 disruption, whereas mesenchymal GSCs are preferentially sensitive to BMI1 inhibition. Given that glioblastomas contain both proneural and mesenchymal GSCs, combined EZH2 and BMI1 targeting proved more effective than either agent alone both in culture and in vivo, suggesting that strategies that simultaneously target multiple epigenetic regulators within glioblastomas may be necessary to overcome resistance to therapies caused by intratumoral heterogeneity. Twit Text FOAVip Targeting Glioma Stem Cells through Combined BMI1 and EZH2 Inhibition ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=29035367 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29035367 #FOAvip English Wikipedia <ref>{{Cite pmid|29035367}}</ref> Targeting Glioma Stem Cells through Combined BMI1 and EZH2 Inhibition #MMPMID29035367 Jin X; Kim LJY; Wu Q; Wallace LC; Prager BC; Sanvoranart T; Gimple RC; Wang X; Mack SC; Miller TE; Huang P; Valentim CL; Zhou Qg; Barnholtz-Sloan JS; Bao S; Sloan AE; Rich JN Nat Med 2017[Nov]; 23 (11): 1352-61 PMID29035367show ga Glioblastomas are lethal cancers defined by angiogenesis and pseudopalisading necrosis. Here, we demonstrate that these histological features are associated with distinct transcriptional programs, with vascular regions showing a proneural profile and hypoxic regions a mesenchymal pattern. As these regions harbor glioma stem cells (GSCs), we investigated the epigenetic regulation of these two niches. Proneural, perivascular GSCs activated EZH2, whereas mesenchymal GSCs in hypoxic regions expressed BMI1 protein, which promoted cellular survival under stress, due to downregulation of the E3 ligase, RNF144A. Using both genetic and pharmacologic inhibition, we found that proneural GSCs are preferentially sensitive to EZH2 disruption, whereas mesenchymal GSCs are preferentially sensitive to BMI1 inhibition. Given that glioblastomas contain both proneural and mesenchymal GSCs, combined EZH2 and BMI1 targeting proved more effective than either agent alone both in culture and in vivo, suggesting that strategies that simultaneously target multiple epigenetic regulators within glioblastomas may be necessary to overcome resistance to therapies caused by intratumoral heterogeneity. äTargeting Glioma Stem Cells through Combined BMI1 and EZH2 Inhibition (epmc).pdf DeepDyve Pubget Overpricing