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10.4049/jimmunol.1700250 http://scihub22266oqcxt.onion/10.4049/jimmunol.1700250 C5679450!5679450!28954888     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2017 ; 199 (9): 3270-9 Nephropedia Template TP {{tp|p=28954888|t=2017. Type III interferons are commonly induced by bacteria-sensing TLRs, and reinforce epithelial barriers during infection |pdf=|usr=}}{{28954888}} gab.com Text Type III interferons are commonly induced by bacteria-sensing TLRs, and reinforce epithelial barriers during infection JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28954888 #FOAvip Type III interferons (IFN?s) are secreted factors that are well-known for their antiviral activities. However, their regulation and functions during bacterial infections are unclear. Herein, we report that the regulation of IFN? genes did not track with mechanisms that control type I IFN expression in response to Toll-like Receptors (TLRs). While type I IFNs were only expressed from TLRs present on endosomes, type III IFNs could be induced by TLRs that reside at the plasma membrane and that detect various bacterial products. The mechanisms that regulate type III IFN gene expression tracked with those that promote inflammatory cytokine and chemokine expression. Importantly, recombinant IFN?s enhanced epithelial barriers in vitro, preventing transcellular bacteria dissemination. We therefore propose that in addition to their functions in cell-intrinsic antiviral immunity, type III IFNs protect epithelial barrier integrity, an activity that would benefit the host during any infectious encounter. Twit Text FOAVip Type III interferons are commonly induced by bacteria-sensing TLRs, and reinforce epithelial barriers during infection ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28954888 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28954888 #FOAvip English Wikipedia <ref>{{Cite pmid|28954888}}</ref> Type III interferons are commonly induced by bacteria-sensing TLRs, and reinforce epithelial barriers during infection #MMPMID28954888 Odendall C; Voak AA; Kagan JC J Immunol 2017[Nov]; 199 (9): 3270-9 PMID28954888show ga Type III interferons (IFN?s) are secreted factors that are well-known for their antiviral activities. However, their regulation and functions during bacterial infections are unclear. Herein, we report that the regulation of IFN? genes did not track with mechanisms that control type I IFN expression in response to Toll-like Receptors (TLRs). While type I IFNs were only expressed from TLRs present on endosomes, type III IFNs could be induced by TLRs that reside at the plasma membrane and that detect various bacterial products. The mechanisms that regulate type III IFN gene expression tracked with those that promote inflammatory cytokine and chemokine expression. Importantly, recombinant IFN?s enhanced epithelial barriers in vitro, preventing transcellular bacteria dissemination. We therefore propose that in addition to their functions in cell-intrinsic antiviral immunity, type III IFNs protect epithelial barrier integrity, an activity that would benefit the host during any infectious encounter. äType III interferons are commonly induced by bacteria-sensing TLRs, an(epmc).pdf DeepDyve Pubget Overpricing