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2017 ; 17
(1
): 714
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Human papillomavirus in semen and the risk for male infertility: a systematic
review and meta-analysis
#MMPMID29121862
Lyu Z
; Feng X
; Li N
; Zhao W
; Wei L
; Chen Y
; Yang W
; Ma H
; Yao B
; Zhang K
; Hu Z
; Shen H
; Hang D
; Dai M
BMC Infect Dis
2017[Nov]; 17
(1
): 714
PMID29121862
show ga
BACKGROUND: Human papillomavirus (HPV) is one of the most prevalent sexually
transmitted viruses. Despite the increasing evidence of HPV prevalence in semen,
the worldwide distribution of HPV types in semen and risk for male infertility
remain inconclusive. METHODS: Four electronic databases were searched for English
language studies conducted between January 1990 and December 2016 that reported
HPV DNA prevalence in semen. Based on the PRISMA guidelines, HPV prevalence was
estimated among general population and fertility clinic attendees, respectively,
and heterogeneity testing was performed using Cochran's Q and I (2) statistics.
The association between HPV positivity and male infertility was evaluated by a
meta-analysis of case-control studies. RESULTS: A total of 31 eligible studies
comprising 5194 males were included. The overall prevalence of HPV DNA in semen
was 11.4% (95% CI?=?7.8-15.0%) in general population (n?=?2122) and 20.4% (95%
CI?=?16.2-24.6%) in fertility clinic attendees (n?=?3072). High-risk type
prevalence was 10.0% (95% CI?=?5.9-14.0%) and 15.5% (95% CI?=?11.4-19.7%),
respectively. HPV16 was the most common type, with a prevalence of 4.8% (95%
CI?=?1.7-7.8%) in general population and 6.0% (95% CI?=?3.8-8.2%) in fertility
clinic attendees. A significantly increased risk of infertility was found for
males with HPV positivity in semen (OR?=?2.93, 95% CI?=?2.03-4.24). CONCLUSIONS:
Seminal HPV infection is common worldwide, which may contribute to the risk of
male infertility.