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10.1038/nnano.2017.170 http://scihub22266oqcxt.onion/10.1038/nnano.2017.170 C5679252!5679252!28892099     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28892099&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Nanotechnol 2017 ; 12 (11): 1096-102 Nephropedia Template TP {{tp|p=28892099|t=2017. Glomerular Barrier Behaves As an Atomically Precise Bandpass Filter in a Sub-nanometer Regime |pdf=|usr=}}{{28892099}} gab.com Text Glomerular Barrier Behaves As an Atomically Precise Bandpass Filter in a Sub-nanometer Regime JO: Nat Nanotechnol http://www.kidney.de/pget.php?&tw=1&pmid=28892099 #FOAvip The glomerular filtration barrier is known as a ?size cut-off? slit to retain nanoparticles or proteins larger than 6~8 nm in the body, and to rapidly excrete the smaller ones through the kidneys. However, in a sub-nm size regime, we found that this barrier behaved as an atomically precise ?bandpass? filter to significantly slow down renal clearance of few-atom gold nanoclusters (AuNCs) with the same surface ligands but different sizes (Au18, Au15 and Au10?11). Compared to Au25 (~1.0 nm), just few-atom decreases in the size resulted in 4~9 times reductions in the renal clearance efficiency in the early elimination stage because the smaller AuNCs were more readily trapped by the glomerular glycocalyx than the larger ones. This unique in vivo nano-bio interaction in the sub-nm regime also slows down the extravasation of sub-nm AuNCs from normal blood vessels and enhances their passive targeting to cancerous tissues through enhanced permeability and retention effect. This discovery highlights the size precision in the body?s response to nanoparticles and opens a new pathway to develop nanomedicines for many diseases associated with glycocalyx dysfunction. Twit Text FOAVip Glomerular Barrier Behaves As an Atomically Precise Bandpass Filter in a Sub-nanometer Regime ????Nat Nanotechnol http://www.kidney.de/pget.php?&tw=1&pmid=28892099 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28892099 #FOAvip English Wikipedia <ref>{{Cite pmid|28892099}}</ref> Glomerular Barrier Behaves As an Atomically Precise Bandpass Filter in a Sub-nanometer Regime #MMPMID28892099 Du B; Jiang X; Das A; Zhou Q; Yu M; Jin R; Zheng J Nat Nanotechnol 2017[Nov]; 12 (11): 1096-102 PMID28892099show ga The glomerular filtration barrier is known as a ?size cut-off? slit to retain nanoparticles or proteins larger than 6~8 nm in the body, and to rapidly excrete the smaller ones through the kidneys. However, in a sub-nm size regime, we found that this barrier behaved as an atomically precise ?bandpass? filter to significantly slow down renal clearance of few-atom gold nanoclusters (AuNCs) with the same surface ligands but different sizes (Au18, Au15 and Au10?11). Compared to Au25 (~1.0 nm), just few-atom decreases in the size resulted in 4~9 times reductions in the renal clearance efficiency in the early elimination stage because the smaller AuNCs were more readily trapped by the glomerular glycocalyx than the larger ones. This unique in vivo nano-bio interaction in the sub-nm regime also slows down the extravasation of sub-nm AuNCs from normal blood vessels and enhances their passive targeting to cancerous tissues through enhanced permeability and retention effect. This discovery highlights the size precision in the body?s response to nanoparticles and opens a new pathway to develop nanomedicines for many diseases associated with glycocalyx dysfunction. äGlomerular Barrier Behaves As an Atomically Precise Bandpass Filter in(epmc).pdf DeepDyve Pubget Overpricing