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10.1084/jem.20161564 http://scihub22266oqcxt.onion/10.1084/jem.20161564 C5679173!5679173 !28947612     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28947612 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Exp+Med 2017 ; 214 (11 ): 3361-3379 Nephropedia Template TP {{tp|p=28947612 |t=2017. Spatially restricted JAG1-Notch signaling in human thymus provides suitable DC developmental niches |pdf=|usr=}}{{28947612 }} gab.com Text Spatially restricted JAG1-Notch signaling in human thymus provides suitable DC developmental niches JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=28947612 #FOAvip A key unsolved question regarding the developmental origin of conventional and plasmacytoid dendritic cells (cDCs and pDCs, respectively) resident in the steady-state thymus is whether early thymic progenitors (ETPs) could escape T cell fate constraints imposed normally by a Notch-inductive microenvironment and undergo DC development. By modeling DC generation in bulk and clonal cultures, we show here that Jagged1 (JAG1)-mediated Notch signaling allows human ETPs to undertake a myeloid transcriptional program, resulting in GATA2-dependent generation of CD34(+) CD123(+) progenitors with restricted pDC, cDC, and monocyte potential, whereas Delta-like1 signaling down-regulates GATA2 and impairs myeloid development. Progressive commitment to the DC lineage also occurs intrathymically, as myeloid-primed CD123(+) monocyte/DC and common DC progenitors, equivalent to those previously identified in the bone marrow, are resident in the normal human thymus. The identification of a discrete JAG1(+) thymic medullary niche enriched for DC-lineage cells expressing Notch receptors further validates the human thymus as a DC-poietic organ, which provides selective microenvironments permissive for DC development. Twit Text FOAVip Spatially restricted JAG1-Notch signaling in human thymus provides suitable DC developmental niches ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=28947612 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28947612 #FOAvip English Wikipedia <ref>{{Cite pmid|28947612 }}</ref> Spatially restricted JAG1-Notch signaling in human thymus provides suitable DC developmental niches #MMPMID28947612 Martín-Gayo E ; González-García S ; García-León MJ ; Murcia-Ceballos A ; Alcain J ; García-Peydró M ; Allende L ; de Andrés B ; Gaspar ML ; Toribio ML J Exp Med 2017[Nov]; 214 (11 ): 3361-3379 PMID28947612 show ga A key unsolved question regarding the developmental origin of conventional and plasmacytoid dendritic cells (cDCs and pDCs, respectively) resident in the steady-state thymus is whether early thymic progenitors (ETPs) could escape T cell fate constraints imposed normally by a Notch-inductive microenvironment and undergo DC development. By modeling DC generation in bulk and clonal cultures, we show here that Jagged1 (JAG1)-mediated Notch signaling allows human ETPs to undertake a myeloid transcriptional program, resulting in GATA2-dependent generation of CD34(+) CD123(+) progenitors with restricted pDC, cDC, and monocyte potential, whereas Delta-like1 signaling down-regulates GATA2 and impairs myeloid development. Progressive commitment to the DC lineage also occurs intrathymically, as myeloid-primed CD123(+) monocyte/DC and common DC progenitors, equivalent to those previously identified in the bone marrow, are resident in the normal human thymus. The identification of a discrete JAG1(+) thymic medullary niche enriched for DC-lineage cells expressing Notch receptors further validates the human thymus as a DC-poietic organ, which provides selective microenvironments permissive for DC development. |*Signal Transduction [MESH] |*Stem Cell Niche [MESH] |Calcium-Binding Proteins [MESH] |Cell Differentiation [MESH] |Cell Lineage [MESH] |Cells, Cultured [MESH] |Dendritic Cells/*metabolism [MESH] |GATA2 Transcription Factor/genetics/metabolism [MESH] |Gene Expression [MESH] |Humans [MESH] |Intercellular Signaling Peptides and Proteins/genetics/metabolism [MESH] |Interleukin-3 Receptor alpha Subunit/metabolism [MESH] |Jagged-1 Protein/genetics/*metabolism [MESH] |Membrane Proteins/genetics/metabolism [MESH] |Microscopy, Confocal [MESH] |Monocytes/cytology/metabolism [MESH] |Myeloid Cells/cytology/metabolism [MESH] |Receptors, Notch/genetics/*metabolism [MESH] |T-Lymphocytes/cytology/metabolism [MESH]Spatially restricted JAG1-Notch signaling in human thymus provides sui(epmc).pdf DeepDyve Pubget Overpricing