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10.1084/jem.20161630 http://scihub22266oqcxt.onion/10.1084/jem.20161630 C5679162!5679162 !28970238     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28970238 &cmd=llinks): Failed to open stream: HTTP request failed! 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HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections |pdf=|usr=}}{{28970238 }} gab.com Text HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=28970238 #FOAvip Transcriptional regulation of numerous interferon-regulated genes, including Toll-like receptor 3 (Tlr3), which encodes an innate immune sensor of viral double-stranded RNA, depends on the interferon regulatory factor 1 (IRF1) and IRF2 transcription factors. We detected specific abrogation of macrophage responses to polyinosinic-polycytidylic acid (poly(I:C)) resulting from three independent N-ethyl-N-nitrosourea-induced mutations in host cell factor C2 (Hcfc2). Hcfc2 mutations compromised survival during influenza virus and herpes simplex virus 1 infections. HCFC2 promoted the binding of IRF1 and IRF2 to the Tlr3 promoter, without which inflammatory cytokine and type I IFN responses to the double-stranded RNA analogue poly(I:C) are reduced in mouse macrophages. HCFC2 was also necessary for the transcription of a large subset of other IRF2-dependent interferon-regulated genes. Deleterious mutations of Hcfc2 may therefore increase susceptibility to diverse infectious diseases. Twit Text FOAVip HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=28970238 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28970238 #FOAvip English Wikipedia <ref>{{Cite pmid|28970238 }}</ref> HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections #MMPMID28970238 Sun L ; Jiang Z ; Acosta-Rodriguez VA ; Berger M ; Du X ; Choi JH ; Wang J ; Wang KW ; Kilaru GK ; Mohawk JA ; Quan J ; Scott L ; Hildebrand S ; Li X ; Tang M ; Zhan X ; Murray AR ; La Vine D ; Moresco EMY ; Takahashi JS ; Beutler B J Exp Med 2017[Nov]; 214 (11 ): 3263-3277 PMID28970238 show ga Transcriptional regulation of numerous interferon-regulated genes, including Toll-like receptor 3 (Tlr3), which encodes an innate immune sensor of viral double-stranded RNA, depends on the interferon regulatory factor 1 (IRF1) and IRF2 transcription factors. We detected specific abrogation of macrophage responses to polyinosinic-polycytidylic acid (poly(I:C)) resulting from three independent N-ethyl-N-nitrosourea-induced mutations in host cell factor C2 (Hcfc2). Hcfc2 mutations compromised survival during influenza virus and herpes simplex virus 1 infections. HCFC2 promoted the binding of IRF1 and IRF2 to the Tlr3 promoter, without which inflammatory cytokine and type I IFN responses to the double-stranded RNA analogue poly(I:C) are reduced in mouse macrophages. HCFC2 was also necessary for the transcription of a large subset of other IRF2-dependent interferon-regulated genes. Deleterious mutations of Hcfc2 may therefore increase susceptibility to diverse infectious diseases. |Animals [MESH] |Cell Line, Tumor [MESH] |Female [MESH] |Gene Expression Regulation/drug effects [MESH] |HEK293 Cells [MESH] |Herpes Simplex/genetics/metabolism/virology [MESH] |Herpesvirus 1, Human/physiology [MESH] |Humans [MESH] |Influenza A Virus, H1N1 Subtype/physiology [MESH] |Interferon Regulatory Factor-1/*genetics/metabolism [MESH] |Interferon Regulatory Factor-2/*genetics/metabolism [MESH] |Kaplan-Meier Estimate [MESH] |Macrophages/drug effects/*metabolism/virology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |NIH 3T3 Cells [MESH] |Orthomyxoviridae Infections/genetics/metabolism/virology [MESH] |Poly I-C/pharmacology [MESH] |Toll-Like Receptor 3/*genetics/metabolism [MESH]HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and fo(epmc).pdf DeepDyve Pubget Overpricing