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10.1038/ni.3837 http://scihub22266oqcxt.onion/10.1038/ni.3837 C5679073!5679073!28892471     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2017 ; 18 (11): 1249-60 Nephropedia Template TP {{tp|p=28892471|t=2017. Dynamic regulation of T Follicular Regulatory cell responses by interleukin 2 during influenza infection |pdf=|usr=}}{{28892471}} gab.com Text Dynamic regulation of T Follicular Regulatory cell responses by interleukin 2 during influenza infection JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28892471 #FOAvip Interleukin 2 (IL-2) promotes Foxp3+-regulatory T (Treg) cell responses, but inhibits T follicular helper (TFH) cell development. However, it is not clear how IL-2 affects T follicular regulatory (TFR) cells, a cell type with properties of both Treg and TFH cells. Using an influenza infection model, we demonstrated that high IL-2 concentrations at the peak of the infection prevented TFR cell development by a Blimp-1?dependent mechanism. However, once the immune response resolved, some Treg cells down-regulated CD25, up-regulated Bcl-6 and differentiated into TFR cells, which then migrated into the B cell follicles to prevent the expansion of self-reactive B cell clones. Thus, unlike its effects on conventional Treg cells, IL-2 inhibits TFR cell responses. Twit Text FOAVip Dynamic regulation of T Follicular Regulatory cell responses by interleukin 2 during influenza infection ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28892471 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28892471 #FOAvip English Wikipedia <ref>{{Cite pmid|28892471}}</ref> Dynamic regulation of T Follicular Regulatory cell responses by interleukin 2 during influenza infection #MMPMID28892471 Botta D; Fuller MJ; Marquez-Lago TT; Bachus H; Bradley JE; Weinmann AS; Zajac AJ; Randall TD; Lund FE; León B; Ballesteros-Tato A Nat Immunol 2017[Nov]; 18 (11): 1249-60 PMID28892471show ga Interleukin 2 (IL-2) promotes Foxp3+-regulatory T (Treg) cell responses, but inhibits T follicular helper (TFH) cell development. However, it is not clear how IL-2 affects T follicular regulatory (TFR) cells, a cell type with properties of both Treg and TFH cells. Using an influenza infection model, we demonstrated that high IL-2 concentrations at the peak of the infection prevented TFR cell development by a Blimp-1?dependent mechanism. However, once the immune response resolved, some Treg cells down-regulated CD25, up-regulated Bcl-6 and differentiated into TFR cells, which then migrated into the B cell follicles to prevent the expansion of self-reactive B cell clones. Thus, unlike its effects on conventional Treg cells, IL-2 inhibits TFR cell responses. äDynamic regulation of T Follicular Regulatory cell responses by interl(epmc).pdf DeepDyve Pubget Overpricing