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Dynamic regulation of T follicular regulatory cell responses by interleukin 2
during influenza infection
#MMPMID28892471
Botta D
; Fuller MJ
; Marquez-Lago TT
; Bachus H
; Bradley JE
; Weinmann AS
; Zajac AJ
; Randall TD
; Lund FE
; León B
; Ballesteros-Tato A
Nat Immunol
2017[Nov]; 18
(11
): 1249-1260
PMID28892471
show ga
Interleukin 2 (IL-2) promotes Foxp3(+) regulatory T (T(reg)) cell responses, but
inhibits T follicular helper (T(FH)) cell development. However, it is not clear
how IL-2 affects T follicular regulatory (T(FR)) cells, a cell type with
properties of both T(reg) and T(FH) cells. Using an influenza infection model, we
found that high IL-2 concentrations at the peak of the infection prevented T(FR)
cell development by a Blimp-1-dependent mechanism. However, once the immune
response resolved, some T(reg) cells downregulated CD25, upregulated Bcl-6 and
differentiated into T(FR) cells, which then migrated into the B cell follicles to
prevent the expansion of self-reactive B cell clones. Thus, unlike its effects on
conventional T(reg) cells, IL-2 inhibits T(FR) cell responses.
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