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10.1016/j.ceb.2017.02.011 http://scihub22266oqcxt.onion/10.1016/j.ceb.2017.02.011 C5678971!5678971!28292700     free     free     free       Curr+Opin+Cell+Biol 2017 ; 45 (ä): 47-54 Nephropedia Template TP {{tp|p=28292700|t=2017. Canonical and Noncanonical Functions of ULK/Atg1 |pdf=|usr=}}{{28292700}} gab.com Text Canonical and Noncanonical Functions of ULK/Atg1 JO: Curr Opin Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28292700 #FOAvip Mammalian Unc-51?like kinases 1 and 2 (ULK1 and ULK2) belong to the ULK/Atg1 family of serine/threonine kinases, which are conserved from yeast to mammals. Although ULK/Atg1 is best known for regulating flux through the autophagy pathway, it has evolutionarily conserved noncanonical functions in protein trafficking that are essential for maintaining cellular homeostasis. As a direct target of energy- and nutrient-sensing kinases, ULK/Atg1 is positioned to regulate the distribution and use of cellular resources in response to metabolic cues. In this review, we provide an overview of the molecular mechanisms through which ULK/Atg1 carries out its canonical and noncanonical functions and the signaling pathways that link its function to metabolism. We also highlight potential contributions of ULK/Atg1 in human diseases, including cancer and neurodegeneration. Twit Text FOAVip Canonical and Noncanonical Functions of ULK/Atg1 ????Curr Opin Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28292700 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28292700 #FOAvip English Wikipedia <ref>{{Cite pmid|28292700}}</ref> Canonical and Noncanonical Functions of ULK/Atg1 #MMPMID28292700 Wang B; Kundu M Curr Opin Cell Biol 2017[Apr]; 45 (ä): 47-54 PMID28292700show ga Mammalian Unc-51?like kinases 1 and 2 (ULK1 and ULK2) belong to the ULK/Atg1 family of serine/threonine kinases, which are conserved from yeast to mammals. Although ULK/Atg1 is best known for regulating flux through the autophagy pathway, it has evolutionarily conserved noncanonical functions in protein trafficking that are essential for maintaining cellular homeostasis. As a direct target of energy- and nutrient-sensing kinases, ULK/Atg1 is positioned to regulate the distribution and use of cellular resources in response to metabolic cues. In this review, we provide an overview of the molecular mechanisms through which ULK/Atg1 carries out its canonical and noncanonical functions and the signaling pathways that link its function to metabolism. We also highlight potential contributions of ULK/Atg1 in human diseases, including cancer and neurodegeneration. äCanonical and Noncanonical Functions of ULK/Atg1 (epmc).pdf DeepDyve Pubget Overpricing