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10.1371/journal.pone.0187447 http://scihub22266oqcxt.onion/10.1371/journal.pone.0187447 C5678728!5678728 !29117211     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29117211 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2017 ; 12 (11 ): e0187447 Nephropedia Template TP {{tp|p=29117211 |t=2017. The treatment of femoral neck fracture using VEGF-loaded nanographene coated internal fixation screws |pdf=|usr=}}{{29117211 }} gab.com Text The treatment of femoral neck fracture using VEGF-loaded nanographene coated internal fixation screws JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29117211 #FOAvip PURPOSE: Previous studies have proved that vascular endothelial growth factor (VEGF) has a dual role in the promotion of new bone formation and blood vessel repair during fracture healing. However, how to introduce VEGF to a fracture site safely and effectively is still a challenge. This study aimed to prepare a VEGF-loaded nanographene coated internal fixation screw and to evaluate its effects in the treatment of femoral neck fracture. METHODS: Nanographene coated screws were prepared by direct liquid-phase exfoliation of the graphite method, and the surface characteristics were observed through scanning electron microscopy (SEM). VEGF was loaded on nanographene coatings through physical adsorption, and the VEGF controlled release was examined by ELISA. Then a canine femoral neck fracture model was built to examine both the angiogenic and osteogenic properties of the VEGF-loaded coated screws. X-ray, micro-CT-based microangiography, and histopathologic evaluation were used to assess the fracture healing progress. RESULTS: The results demonstrated that nanographene could load VEGF effectively, and the accumulative release of VEGF clearly increased during the entire testing period (9 days) without burst release. In canine fracture models, the results of X-ray, microangiography, and histopathologic examination proved that the speed of fracture healing, new bone formation area, and revascularization of the fractured femoral heads in the VEGF-loaded coated screws groups were significantly higher than in the control groups. CONCLUSION: Our study proved that VEGF-loaded nanographene coated screws were effective in the treatment of femoral neck fracture and prevention of avascular necrosis of femoral head. Twit Text FOAVip The treatment of femoral neck fracture using VEGF-loaded nanographene coated internal fixation screws ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29117211 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29117211 #FOAvip English Wikipedia <ref>{{Cite pmid|29117211 }}</ref> The treatment of femoral neck fracture using VEGF-loaded nanographene coated internal fixation screws #MMPMID29117211 Li S ; Yuan H ; Pan J ; Fan W ; Zhu L ; Yan Z ; Guo C PLoS One 2017[]; 12 (11 ): e0187447 PMID29117211 show ga PURPOSE: Previous studies have proved that vascular endothelial growth factor (VEGF) has a dual role in the promotion of new bone formation and blood vessel repair during fracture healing. However, how to introduce VEGF to a fracture site safely and effectively is still a challenge. This study aimed to prepare a VEGF-loaded nanographene coated internal fixation screw and to evaluate its effects in the treatment of femoral neck fracture. METHODS: Nanographene coated screws were prepared by direct liquid-phase exfoliation of the graphite method, and the surface characteristics were observed through scanning electron microscopy (SEM). VEGF was loaded on nanographene coatings through physical adsorption, and the VEGF controlled release was examined by ELISA. Then a canine femoral neck fracture model was built to examine both the angiogenic and osteogenic properties of the VEGF-loaded coated screws. X-ray, micro-CT-based microangiography, and histopathologic evaluation were used to assess the fracture healing progress. RESULTS: The results demonstrated that nanographene could load VEGF effectively, and the accumulative release of VEGF clearly increased during the entire testing period (9 days) without burst release. In canine fracture models, the results of X-ray, microangiography, and histopathologic examination proved that the speed of fracture healing, new bone formation area, and revascularization of the fractured femoral heads in the VEGF-loaded coated screws groups were significantly higher than in the control groups. CONCLUSION: Our study proved that VEGF-loaded nanographene coated screws were effective in the treatment of femoral neck fracture and prevention of avascular necrosis of femoral head. |*Bone Screws [MESH] |*Fracture Fixation, Internal [MESH] |Animals [MESH] |Bone Density/drug effects [MESH] |Cell Death/drug effects [MESH] |Coated Materials, Biocompatible/*pharmacology [MESH] |Dogs [MESH] |Female [MESH] |Femoral Neck Fractures/diagnostic imaging/pathology/*surgery [MESH] |Femur Head/diagnostic imaging/drug effects/pathology [MESH] |Graphite/*pharmacology [MESH] |Human Umbilical Vein Endothelial Cells/drug effects [MESH] |Humans [MESH] |Imaging, Three-Dimensional [MESH] |Male [MESH] |Microvessels/diagnostic imaging [MESH] |Nanoparticles/*chemistry/ultrastructure [MESH] |Osteoblasts/cytology/drug effects [MESH] |Platelet Endothelial Cell Adhesion Molecule-1/metabolism [MESH]The treatment of femoral neck fracture using VEGF-loaded nanographene (epmc).pdf DeepDyve Pubget Overpricing