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10.1016/j.ekir.2016.08.016

http://scihub22266oqcxt.onion/10.1016/j.ekir.2016.08.016
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C5678675!5678675!29142937
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suck abstract from ncbi


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pmid29142937      Kidney+Int+Rep 2017 ; 2 (1): 5-17
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  • Geographic Variation and US County Characteristics Associated With Rapid Kidney Function Decline #MMPMID29142937
  • Bowe B; Xie Y; Xian H; Lian M; Al-Aly Z
  • Kidney Int Rep 2017[Jan]; 2 (1): 5-17 PMID29142937show ga
  • Introduction: Geographic variation in the prevalence of chronic kidney disease and incidence of end-stage renal disease has been previously reported. However, the geographic epidemiology of rapid estimated glomerular filtration rate (eGFR) decline has not been examined. Methods: We built a longitudinal cohort of 2,107,570 US veterans to characterize the spatial epidemiology of and examine the associations between US county characteristics and rapid eGFR decline. Results: There were 169,029 (8.02%) with rapid eGFR decline (defined as eGFR slope < ?5 ml/min per 1.73 m2/year). The prevalence of rapid eGFR decline adjusted for age, race, gender, diabetes, and hypertension varied by county from 4.10%?6.72% in the lowest prevalence quintile to 8.41%?22.04% in the highest prevalence quintile (P for heterogeneity < 0.001). Examination of adjusted prevalence showed substantial geographic variation in those with and without diabetes and those with and without hypertension (P for heterogeneity < 0.001). Cohort participants had higher odds of rapid eGFR decline when living in counties with unfavorable characteristics in domains including health outcomes (odds ratio [OR] = 1.15; confidence interval [CI] = 1.09?1.22), health behaviors (OR = 1.08; CI = 1.03?1.13), clinical care (OR = 1.11; CI = 1.06?1.16), socioeconomic conditions (OR = 1.15; CI = 1.09?1.22), and physical environment (OR = 1.15; CI = 1.01?1.20); living in counties with high percentage of minorities and immigrants was associated with rapid eGFR decline (OR = 1.25; CI = 1.20?1.31). Spatial analyses suggest the presence of cluster of counties with high prevalence of rapid eGFR decline. Discussion: Our findings show substantial geographic variation in rapid eGFR decline among US veterans; the variation persists in analyses stratified by diabetes and hypertension status; results show associations between US county characteristics in domains capturing health, socioeconomic, environmental, and diversity conditions, and rapid eGFR decline.
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