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10.1016/j.ekir.2017.02.005 http://scihub22266oqcxt.onion/10.1016/j.ekir.2017.02.005 C5678660!5678660!29142962     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Kidney+Int+Rep 2017 ; 2 (3): 318-31 Nephropedia Template TP {{tp|p=29142962|t=2017. What Genetics Tells Us About the Pathogenesis of IgA Nephropathy: The Role of Immune Factors and Infection |pdf=|usr=}}{{29142962}} gab.com Text What Genetics Tells Us About the Pathogenesis of IgA Nephropathy: The Role of Immune Factors and Infection JO: Kidney Int Rep http://www.kidney.de/pget.php?&tw=1&pmid=29142962 #FOAvip Immunoglobulin A nephropathy (IgAN) is the most common type of primary glomerulonephritis, which is characterized by IgA1-containing immune-deposits in the glomerular mesangium. The epidemiologic observations of familial clustering as well as ethnic and regional discrepancies indicate a genetic component to IgAN. Large, international, genome-wide association studies have identified several susceptibility genes and loci for IgAN, many of which have been implicated in immune regulation and are shared with other autoimmune diseases. Notably, increasing numbers of genes involved in mucosal immunity have been detected; such genes may impact the susceptibility and progression of IgAN through interaction with environmental stimuli (especially infection). Here, we discuss the innate and adaptive immune mechanisms that drive protective immunity against pathogens. Our goal is to provide a representative overview of the synergistic roles between genetic predisposition and infection in IgAN pathogenesis. We anticipate that these results will provide potential therapeutic agents and advances in precision medicine. Twit Text FOAVip What Genetics Tells Us About the Pathogenesis of IgA Nephropathy: The Role of Immune Factors and Infection ????Kidney Int Rep http://www.kidney.de/pget.php?&tw=1&pmid=29142962 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29142962 #FOAvip English Wikipedia <ref>{{Cite pmid|29142962}}</ref> What Genetics Tells Us About the Pathogenesis of IgA Nephropathy: The Role of Immune Factors and Infection #MMPMID29142962 Zhang YM; Zhou XJ; Zhang H Kidney Int Rep 2017[May]; 2 (3): 318-31 PMID29142962show ga Immunoglobulin A nephropathy (IgAN) is the most common type of primary glomerulonephritis, which is characterized by IgA1-containing immune-deposits in the glomerular mesangium. The epidemiologic observations of familial clustering as well as ethnic and regional discrepancies indicate a genetic component to IgAN. Large, international, genome-wide association studies have identified several susceptibility genes and loci for IgAN, many of which have been implicated in immune regulation and are shared with other autoimmune diseases. Notably, increasing numbers of genes involved in mucosal immunity have been detected; such genes may impact the susceptibility and progression of IgAN through interaction with environmental stimuli (especially infection). Here, we discuss the innate and adaptive immune mechanisms that drive protective immunity against pathogens. Our goal is to provide a representative overview of the synergistic roles between genetic predisposition and infection in IgAN pathogenesis. We anticipate that these results will provide potential therapeutic agents and advances in precision medicine. äWhat Genetics Tells Us About the Pathogenesis of IgA Nephropathy: The (epmc).pdf DeepDyve Pubget Overpricing