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10.3892/ol.2017.7007 http://scihub22266oqcxt.onion/10.3892/ol.2017.7007 C5678423!5678423!29151919     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncol+Lett 2017 ; 14 (6): 6929-36 Nephropedia Template TP {{tp|p=29151919|t=2017. miR-21 is involved in transforming growth factor ?1-induced chemoresistance and invasion by targeting PTEN in breast cancer |pdf=|usr=}}{{29151919}} gab.com Text miR-21 is involved in transforming growth factor 1-induced chemoresistance and invasion by targeting PTEN in breast cancer JO: Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=29151919 #FOAvip Transforming growth factor ?1 (TGF-?1) has been associated with poor outcomes in patients with breast cancer. However, the functions and underlying molecular mechanisms of TGF-?1 in breast cancer remain unknown. Therefore, the present study aimed to identify the effects of components of the TGF-?/microRNA (miR-)21/phosphatase and tensin homolog (PTEN) signaling axis in breast cancer. TGF-?1 was identified to upregulate the expression of miR-21, and miR-21 was demonstrated to be significantly upregulated in breast cancer tissues compared with benign proliferative breast disease. In addition, the expression of miR-21 was significantly associated with increased TGF-?1 and clinical characteristics in patients, including tumor grade and lymph node metastasis (all P<0.05). Furthermore, in the breast cancer MCF-7 cell line, TGF-?1 was revealed to induce the expression of miR-21 in a dose- and time-dependent manner. The results of the present study additionally demonstrated that increased miR-21, in response to TGF-?1 signaling, was associated with tumor invasion and chemoresistance in vitro. In addition, suppression of PTEN was mediated by TGF-?1-induced expression of miR-21 in breast cancer cells and using a miR-21 inhibitor revitalized the expression of PTEN. The results of the present study explored the functions of TGF-?1-stimulated expression of miR-21 to suppress the PTEN axis, which promotes breast cancer progression and chemoresistance. Twit Text FOAVip miR-21 is involved in transforming growth factor 1-induced chemoresistance and invasion by targeting PTEN in breast cancer ????Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=29151919 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29151919 #FOAvip English Wikipedia <ref>{{Cite pmid|29151919}}</ref> miR-21 is involved in transforming growth factor ?1-induced chemoresistance and invasion by targeting PTEN in breast cancer #MMPMID29151919 Dai X; Fang M; Li S; Yan Y; Zhong Y; Du B Oncol Lett 2017[Dec]; 14 (6): 6929-36 PMID29151919show ga Transforming growth factor ?1 (TGF-?1) has been associated with poor outcomes in patients with breast cancer. However, the functions and underlying molecular mechanisms of TGF-?1 in breast cancer remain unknown. Therefore, the present study aimed to identify the effects of components of the TGF-?/microRNA (miR-)21/phosphatase and tensin homolog (PTEN) signaling axis in breast cancer. TGF-?1 was identified to upregulate the expression of miR-21, and miR-21 was demonstrated to be significantly upregulated in breast cancer tissues compared with benign proliferative breast disease. In addition, the expression of miR-21 was significantly associated with increased TGF-?1 and clinical characteristics in patients, including tumor grade and lymph node metastasis (all P<0.05). Furthermore, in the breast cancer MCF-7 cell line, TGF-?1 was revealed to induce the expression of miR-21 in a dose- and time-dependent manner. The results of the present study additionally demonstrated that increased miR-21, in response to TGF-?1 signaling, was associated with tumor invasion and chemoresistance in vitro. In addition, suppression of PTEN was mediated by TGF-?1-induced expression of miR-21 in breast cancer cells and using a miR-21 inhibitor revitalized the expression of PTEN. The results of the present study explored the functions of TGF-?1-stimulated expression of miR-21 to suppress the PTEN axis, which promotes breast cancer progression and chemoresistance. ämiR-21 is involved in transforming growth factor ?1-induced chemoresis(epmc).pdf DeepDyve Pubget Overpricing