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10.1038/s41598-017-15602-3 http://scihub22266oqcxt.onion/10.1038/s41598-017-15602-3 C5678128!5678128 !29118394     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29118394 &cmd=llinks): Failed to open stream: HTTP request failed! 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An apelin receptor antagonist prevents pathological retinal angiogenesis with ischemic retinopathy in mice |pdf=|usr=}}{{29118394 }} gab.com Text An apelin receptor antagonist prevents pathological retinal angiogenesis with ischemic retinopathy in mice JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29118394 #FOAvip Pathological retinal angiogenesis is caused by the progression of ischemic retinal diseases and can result in retinal detachment and irreversible blindness. This neovascularization is initiated from the retinal veins and their associated capillaries and involves the overgrowth of vascular endothelial cells. Since expression of the apelin receptor (APJ) is restricted to the veins and proliferative endothelial cells during physiological retinal angiogenesis, in the present study, we investigated the effect of APJ inhibition on pathological retinal angiogenesis in a mouse model of oxygen-induced retinopathy (OIR). In vitro experiments revealed that ML221, an APJ antagonist, suppressed cultured-endothelial cell proliferation in a dose-dependent manner. Intraperitoneal administration of ML221 inhibited pathological angiogenesis but enhanced the recovery of normal vessels into the ischemic regions in the retina of the OIR model mice. ML221 did not affect the expression levels of vascular endothelial growth factor (VEGF) and its receptor (VEGFR2) in the retina. APJ was highly expressed in the endothelial cells within abnormal vessels but was only detected in small amounts in morphologically normal vessels. These results suggest that APJ inhibitors selectively prevent pathological retinal angiogenesis and that the drugs targeting APJ may be new a candidate for treating ischemic retinopathy. Twit Text FOAVip An apelin receptor antagonist prevents pathological retinal angiogenesis with ischemic retinopathy in mice ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29118394 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29118394 #FOAvip English Wikipedia <ref>{{Cite pmid|29118394 }}</ref> An apelin receptor antagonist prevents pathological retinal angiogenesis with ischemic retinopathy in mice #MMPMID29118394 Ishimaru Y ; Shibagaki F ; Yamamuro A ; Yoshioka Y ; Maeda S Sci Rep 2017[Nov]; 7 (1 ): 15062 PMID29118394 show ga Pathological retinal angiogenesis is caused by the progression of ischemic retinal diseases and can result in retinal detachment and irreversible blindness. This neovascularization is initiated from the retinal veins and their associated capillaries and involves the overgrowth of vascular endothelial cells. Since expression of the apelin receptor (APJ) is restricted to the veins and proliferative endothelial cells during physiological retinal angiogenesis, in the present study, we investigated the effect of APJ inhibition on pathological retinal angiogenesis in a mouse model of oxygen-induced retinopathy (OIR). In vitro experiments revealed that ML221, an APJ antagonist, suppressed cultured-endothelial cell proliferation in a dose-dependent manner. Intraperitoneal administration of ML221 inhibited pathological angiogenesis but enhanced the recovery of normal vessels into the ischemic regions in the retina of the OIR model mice. ML221 did not affect the expression levels of vascular endothelial growth factor (VEGF) and its receptor (VEGFR2) in the retina. APJ was highly expressed in the endothelial cells within abnormal vessels but was only detected in small amounts in morphologically normal vessels. These results suggest that APJ inhibitors selectively prevent pathological retinal angiogenesis and that the drugs targeting APJ may be new a candidate for treating ischemic retinopathy. |Animals [MESH] |Apelin Receptors/*antagonists & inhibitors/genetics/metabolism [MESH] |Apelin/genetics/metabolism [MESH] |Cell Proliferation/drug effects [MESH] |Cells, Cultured [MESH] |Disease Models, Animal [MESH] |Endothelial Cells/cytology/drug effects [MESH] |Gene Expression/drug effects [MESH] |Ischemia/genetics/metabolism/prevention & control [MESH] |Mice [MESH] |Nitrobenzoates/*pharmacology [MESH] |Pyrans/*pharmacology [MESH] |Retinal Diseases/genetics/metabolism/*prevention & control [MESH] |Retinal Neovascularization/genetics/metabolism/*prevention & control [MESH] |Vascular Endothelial Growth Factor A/genetics/metabolism [MESH]An apelin receptor antagonist prevents pathological retinal angiogenes(epmc).pdf DeepDyve Pubget Overpricing