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10.1073/pnas.1713625114 http://scihub22266oqcxt.onion/10.1073/pnas.1713625114 C5676932!5676932!29078390     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (44): E9308-17 Nephropedia Template TP {{tp|p=29078390|t=2017. WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy |pdf=|usr=}}{{29078390}} gab.com Text WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29078390 #FOAvip We present an identification of the relevance of WD40-repeat (WDR) genes in brain connectivity, highlighting the power of unbiased mouse studies in the field of neuroscience. We focus on the poorly studied WDR47 protein sharing structural homology with LIS1, which causes lissencephaly. WDR47 plays a role in progenitor proliferation, neuronal migration, and fiber tract projections in a similar fashion to LIS1 but with the distinctive particularity that WDR47 inhibits autophagic flux. This provides a functional link between autophagy biology and the C-terminal to LisH domain in mammals. Importantly, WDR47 uncovers an aspect of corpus callosum biology pointing toward a link between the regulation of microtubule dynamics and autophagic flux for axonal outgrowth and guidance. Twit Text FOAVip WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29078390 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29078390 #FOAvip English Wikipedia <ref>{{Cite pmid|29078390}}</ref> WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy #MMPMID29078390 Kannan M; Bayam E; Wagner C; Rinaldi B; Kretz PF; Tilly P; Roos M; McGillewie L; Bär S; Minocha S; Chevalier C; Po C; Chelly J; Mandel JL; Borgatti R; Piton A; Kinnear C; Loos B; Adams DJ; Hérault Y; Collins SC; Friant S; Godin JD; Yalcin B; Vancollie VE; Anthony LFE; Maguire SA; Lafont D; Pearson SA; Gates AS; Sanderson M; Shannon C; Sumowski MT; McLaren-Jones RSB; Swiatkowska A; Isherwood CM; Cambridge EL; Wilson HM; Caetano SS; Maguire AKB; Galli A; Speak AO; Dench J; Tuck E; Estabel J; Green A; Tudor C; Siragher E; Dabrowska M; Mazzeo CI; Hooks Y; Kussy F; Griffiths M; Gannon D; Doe B; Boroviak K; Wardle-Jones H; Griggs N; Bottomley J; Ryder E; Gleeson D; White JK; Ramirez-Solis R; Lelliott CJ Proc Natl Acad Sci U S A 2017[Oct]; 114 (44): E9308-17 PMID29078390show ga We present an identification of the relevance of WD40-repeat (WDR) genes in brain connectivity, highlighting the power of unbiased mouse studies in the field of neuroscience. We focus on the poorly studied WDR47 protein sharing structural homology with LIS1, which causes lissencephaly. WDR47 plays a role in progenitor proliferation, neuronal migration, and fiber tract projections in a similar fashion to LIS1 but with the distinctive particularity that WDR47 inhibits autophagic flux. This provides a functional link between autophagy biology and the C-terminal to LisH domain in mammals. Importantly, WDR47 uncovers an aspect of corpus callosum biology pointing toward a link between the regulation of microtubule dynamics and autophagic flux for axonal outgrowth and guidance. äWD40-repeat 47, a microtubule-associated protein, is essential for bra(epmc).pdf DeepDyve Pubget Overpricing