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10.1073/pnas.1708420114 http://scihub22266oqcxt.onion/10.1073/pnas.1708420114 C5676906!5676906 !29078330     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29078330 &cmd=llinks): Failed to open stream: HTTP request failed! 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Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes |pdf=|usr=}}{{29078330 }} gab.com Text Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29078330 #FOAvip Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we developed a strategy to macroencapsulate islets from different sources that allow their survival and function without immunosuppression. Here we report successful and safe transplantation of porcine islets with a bioartificial pancreas device in diabetic primates without any immune suppression. This strategy should lead to pioneering clinical trials with xenotransplantation for treatment of diabetes and, thereby, represents a previously unidentified approach to efficient cell replacement for a broad spectrum of endocrine disorders and other organ dysfunctions. Twit Text FOAVip Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29078330 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29078330 #FOAvip English Wikipedia <ref>{{Cite pmid|29078330 }}</ref> Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes #MMPMID29078330 Ludwig B ; Ludwig S ; Steffen A ; Knauf Y ; Zimerman B ; Heinke S ; Lehmann S ; Schubert U ; Schmid J ; Bleyer M ; Schönmann U ; Colton CK ; Bonifacio E ; Solimena M ; Reichel A ; Schally AV ; Rotem A ; Barkai U ; Grinberg-Rashi H ; Kaup FJ ; Avni Y ; Jones P ; Bornstein SR Proc Natl Acad Sci U S A 2017[Oct]; 114 (44 ): 11745-11750 PMID29078330 show ga Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we developed a strategy to macroencapsulate islets from different sources that allow their survival and function without immunosuppression. Here we report successful and safe transplantation of porcine islets with a bioartificial pancreas device in diabetic primates without any immune suppression. This strategy should lead to pioneering clinical trials with xenotransplantation for treatment of diabetes and, thereby, represents a previously unidentified approach to efficient cell replacement for a broad spectrum of endocrine disorders and other organ dysfunctions. |Animals [MESH] |Diabetes Mellitus, Experimental/*surgery [MESH] |Diabetes Mellitus, Type 1/*surgery/*therapy [MESH] |Female [MESH] |Immunosuppression Therapy/methods [MESH] |Islets of Langerhans Transplantation/methods [MESH] |Islets of Langerhans/*surgery [MESH] |Primates [MESH] |Swine [MESH]Favorable outcome of experimental islet xenotransplantation without (epmc).pdf DeepDyve Pubget Overpricing