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10.1073/pnas.1703921114 http://scihub22266oqcxt.onion/10.1073/pnas.1703921114 C5676879!5676879!29078276     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29078276&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (44): E9271-9 Nephropedia Template TP {{tp|p=29078276|t=2017. Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner |pdf=|usr=}}{{29078276}} gab.com Text Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29078276 #FOAvip The failure in achieving a durable clinical immune response against cancer cells depends on the ability of cancer cells to establish a microenvironment that prevent cytotoxic immune cells to infiltrate tumors and kill cancer cells. Therefore, the key approach to achieving successful antitumor immune response is to harness strategies allowing the reorientation of immune cells to the tumor. Herein we reveal that inhibiting autophagy induces a massive infiltration of natural killer immune cells into the tumor bed, and a subsequent dramatic decrease in the tumor volume of melanomas. These results highlight the role of targeting autophagy in breaking the immunosuppressive tumor microenvironment barrier, thus allowing the infiltration of natural killer cells into the tumor to kill cancer cells. Twit Text FOAVip Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29078276 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29078276 #FOAvip English Wikipedia <ref>{{Cite pmid|29078276}}</ref> Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner #MMPMID29078276 Mgrditchian T; Arakelian T; Paggetti J; Noman MZ; Viry E; Moussay E; Van Moer K; Kreis S; Guerin C; Buart S; Robert C; Borg C; Vielh P; Chouaib S; Berchem G; Janji B Proc Natl Acad Sci U S A 2017[Oct]; 114 (44): E9271-9 PMID29078276show ga The failure in achieving a durable clinical immune response against cancer cells depends on the ability of cancer cells to establish a microenvironment that prevent cytotoxic immune cells to infiltrate tumors and kill cancer cells. Therefore, the key approach to achieving successful antitumor immune response is to harness strategies allowing the reorientation of immune cells to the tumor. Herein we reveal that inhibiting autophagy induces a massive infiltration of natural killer immune cells into the tumor bed, and a subsequent dramatic decrease in the tumor volume of melanomas. These results highlight the role of targeting autophagy in breaking the immunosuppressive tumor microenvironment barrier, thus allowing the infiltration of natural killer cells into the tumor to kill cancer cells. äTargeting autophagy inhibits melanoma growth by enhancing NK cells inf(epmc).pdf DeepDyve Pubget Overpricing